MLi-2 - CAS 1627091-47-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H25N5O2
Molecular Weight:
379.46
COA:
Inquire
Targets:
LRRK2
Description:
MLi-2 is a potent, orally available and brain penetrant inhibitor of LRRK2 (IC50= 0.76 nM) with excellent selectivity that shows >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels.
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Brife Description:
A potent and selective LRRK2 inhibitor (IC50= 0.76 nM)
Synonyms:
(2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine; MLi-2; MLi 2; MLi2
Solubility:
DMSO: ≥ 26 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
625.8±55.0 ℃ at 760 Torr
Density:
1.257±0.06 g/cm3
InChIKey:
ATUUNJCZCOMUKD-OKILXGFUSA-N
InChI:
1S/C21H25N5O2/c1-13-10-26(11-14(2)27-13)19-9-18(22-12-23-19)20-16-8-15(28-21(3)6-7-21)4-5-17(16)24-25-20/h4-5,8-9,12-14H,6-7,10-11H2,1-3H3,(H,24,25)/t13-,14+
Canonical SMILES:
CC1CN(CC(O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C
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CAS 1627091-47-7 MLi-2

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