|Description||ML385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM), and blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin and other chemotherapeutic drugs in lung cancer cells (NSCLC).|
|Brife Description||A potent and selective NRF2 inhibitor (Nrf2; IC50 = 1.9 µM)|
|Synonyms||2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide; ML-385; ML 385|
|Solubility||DMSO: ≥ 30 mg/mL|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).
Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant i...
ML385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM), and blocks NRF2 transcriptional activity, and enha...
RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe...
Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is ca...
Dimethyl fumarate is an anti-inflammatory, a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with relapsing...
CDDO-EA is an activator of Nrf2/ARE. It has neuroprotective effect.