ML385 - CAS 846557-71-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H25N3O4S
Molecular Weight:
511.6
COA:
Inquire
Targets:
KEAP1-Nrf2
Description:
ML385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM), and blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin and other chemotherapeutic drugs in lung cancer cells (NSCLC).
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
A potent and selective NRF2 inhibitor (Nrf2; IC50 = 1.9 µM)
Synonyms:
2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide; ML-385; ML 385
Solubility:
DMSO: ≥ 30 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Density:
1.374±0.06 g/cm3
InChIKey:
LINHYWKZVCNAMQ-UHFFFAOYSA-N
InChI:
1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
Canonical SMILES:
CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related KEAP1-Nrf2 Products


CAS 458-37-7 Curcumin

Curcumin
(CAS: 458-37-7)

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae).

CAS 218600-53-4 Bardoxolone methyl

Bardoxolone methyl
(CAS: 218600-53-4)

Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant i...

CAS 846557-71-9 ML385

ML385
(CAS: 846557-71-9)

ML385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM), and blocks NRF2 transcriptional activity, and enha...

CAS 1474034-05-3 RTA-408

RTA-408
(CAS: 1474034-05-3)

RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe...

CAS 218600-44-3 Bardoxolone

Bardoxolone
(CAS: 218600-44-3)

Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is ca...

CAS 624-49-7 Dimethyl Fumarate

Dimethyl Fumarate
(CAS: 624-49-7)

Dimethyl fumarate is an anti-inflammatory, a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with relapsing...

CAS 932730-51-3 CDDO-EA

CDDO-EA
(CAS: 932730-51-3)

CDDO-EA is an activator of Nrf2/ARE. It has neuroprotective effect.

Chemical Structure

CAS 846557-71-9 ML385

Quick Inquiry

Verification code

Featured Items