ML337 - CAS 1443118-44-2
Catalog number:
1443118-44-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H20FNO3
Molecular Weight:
353.39
COA:
Inquire
Targets:
mGluR
Description:
ML337 is a Selective negative allosteric modulator of mGlu3 with IC50 value of 593 nM. It shows no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. ML337 is a best-in-class probe for studying non-competitive antagonism of mGlu3.
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Purity:
98%
Appearance:
Off-white solid
Synonyms:
CHEMBL2385886; ML337; ML 337; ML-337; MLS004580699; GTPL8765;(R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone
Solubility:
DMSO to 100 mM ethanol to 20 mM
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
in vitro and in vivo probe for studying non-competitive antagonism of mGlu3
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
QBCRLDPMQHPGIM-QGZVFWFLSA-N
InChI:
InChI=1S/C21H20FNO3/c1-26-18-9-6-15(7-10-18)4-5-16-8-11-19(20(22)13-16)21(25)23-12-2-3-17(24)14-23/h6-11,13,17,24H,2-3,12,14H2,1H3/t17-/m1/s1
Canonical SMILES:
COC1=CC=C(C=C1)C#CC2=CC(=C(C=C2)C(=O)N3CCCC(C3)O)F
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