ML311 - CAS 315698-17-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H24F3N3O
Molecular Weight:
415.46
COA:
Inquire
Targets:
Bcl-2 Family
Description:
ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-positive BC cells in a dose-dependent manner. ML311 is a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.
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Appearance:
Solid powder
Synonyms:
7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol; ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
515.7±45.0 °C at 760 Torr
Density:
1.268±0.06 g/cm3
InChIKey:
NGAPBLRRJSKIRT-UHFFFAOYSA-N
InChI:
1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3
Canonical SMILES:
OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4
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Chemical Structure

CAS 315698-17-0 ML311

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