ML216 - CAS 1430213-30-1
Catalog number: 1430213-30-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H9F4N5OS
Molecular Weight:
383.32
COA:
Inquire
Targets:
Others
Description:
Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.
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Purity:
>98%
Synonyms:
ML 216; ML-216; CID-49852229; CID49852229; CID 49852229
MSDS:
Inquire
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CAS 1430213-30-1 ML216

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