ML-9 hydrochloride - CAS 105637-50-1
Catalog number:
105637-50-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H18Cl2N2O2S
Molecular Weight:
361.29
COA:
Inquire
Description:
ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
White powder
Synonyms:
ML9 Hydrochloride;1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride
Solubility:
Ethanol: 10 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
ML-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. It may be a new type of vascular relaxant.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
508.8ºC at 760mmHg
Melting Point:
196-200ºC
InChIKey:
ZNRYCIVTNLZOGI-UHFFFAOYSA-N
InChI:
InChI=1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
Canonical SMILES:
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3Cl.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Chemical Structure

CAS 105637-50-1 ML-9 hydrochloride

Quick Inquiry

Verification code

Featured Items