ML-365 - CAS 947914-18-3
Catalog number:
947914-18-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H20N2O3
Molecular Weight:
360.41
COA:
Inquire
Targets:
Potassium Channel
Description:
ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies.
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Purity:
>98 %
Appearance:
White to off-white Solid
Synonyms:
2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide;ML365
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
ML365 is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
429.9±40.0 °C | Condition: Press: 760 Torr
Density:
1.253±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
UTAJHKSGYJSZBR-UHFFFAOYSA-N
InChI:
InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
Canonical SMILES:
CC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2)NC(=O)C3=CC=CC=C3OC
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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