|Description||ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies.|
|Appearance||White to off-white Solid|
|Solubility||10 mM in DMSO|
|Application||ML365 is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||429.9±40.0 °C | Condition: Press: 760 Torr|
|Density||1.253±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiol...
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