LDN-57444 is a reversible, competitive proteasome inhibitor for UCH-L1 with IC50 of 0.88 μM, 28-fold greater selectivity over isoform UCH-L3.
DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor for USP8. It is 30 fold selectivity over USP7.
b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal in...
HBX 19818 exhibited a dose-dependent effect on USP7 activity. HBX 19,818 efficiently blocked labeling of USP7 but not that of USP8, USP5, USP10, CYLD, or UCH-L3...
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 ...
Degrasyn, also known as WP1130, is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr...
DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor for USP7/USP8.
USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, ...
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. It inhibited the Ub-VS labeling of a...
P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis...
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor for USP7/USP8.
P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). P005091 induces elevated p53 and apoptosis in cancer cell li...
ML364 is a small molecule, reversible inhibitor of the deubiquitinase USP2, that has an IC50 value of 1.1 µM in a fluorescence-based assay using di-ubiquitin su...