ML-030 - CAS 1013750-77-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H20N4O4S
Molecular Weight:
412.46
COA:
Inquire
Targets:
Phosphodiesterase (PDE)
Description:
ML-030, a triazolothiadiazine, is a potent PDE4 inhibitor in a cell-based cyclic nucleotide-gated cation channel biosensor assay (EC50 = 18.7 nM), with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.
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Synonyms:
3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
Solubility:
DMSO: ≥ 100 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
633.2±65.0 ℃ at 760 Torr
Density:
1.36±0.1 g/cm3
InChIKey:
DZAUSKKPHXFGNN-UHFFFAOYSA-N
InChI:
1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
Canonical SMILES:
COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC
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CAS 1013750-77-0 ML-030

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