MKC-1 - CAS 125313-92-0
Catalog number:
125313-92-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.
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Synonyms:
R 440; Ro 31-7453
MSDS:
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Current Developer:
EntreMed, Inc.
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CAS 125313-92-0 MKC-1

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