|Description||MK212 hydrochloride is a selective 5-HT2C serotonin receptor agonist. It displays selectivity for 5-HT2C over 5-HT2A with IC50 values of 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively.|
|Appearance||White to off-white powder|
|Synonyms||MK-212 hydrochloride;1-(6-Chloro-2-pyrazinyl)piperazine monohydrochloride;2-Chloro-6-(1-piperazinyl)pyrazine monohydrochloride|
|Solubility||DMSO: ≥20 mg/mL|
|Quality Standard||In-house standard|
(+)-MDL 105725 is an active metabolite of MDL 100907, which is a selective 5-HT2A antagonist.
PR-073 is a novel 5-HT7 antagonist, which can inhibit immune responses and treat inflammatory bowel disease (IBD). Preclinical studies demonstrated that PR-073 ...
LY 302148 is a 5-HT1F receptor agonist with potential for migraine therapeutics.
RU 24969 hemisuccinate
RU 24969 hemisuccinate is a potent and selective agonist at the 5-HT1A and 5-HT1B receptors. It is centrally active following systemic administration.
Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide for the treatment of vascular headache
MDL 100009 is the S-enantiomer of MDL 100151, which is a selective 5-HT2A antagonist.
Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...
LY 344864 racemate
LY 344864 racemate is a 5-HT1F receptor agonist.
m-Chlorophenylbiguanide hydrochloride is the hydrochloride salt of chlorophenylbiguanide, which is a selective and prototypical potent 5-HT3 serotonin receptor ...
Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. It is a ...
GYKI-46903 is a Muscarinic M3 receptor and Serotonin 3 receptor antagonist. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron bind...
BMY 14802 hydrochloride
BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with weak affinity for 5-HT1A and α1 receptors. BMY 14802 is potentially used as a...
BIMU 8 is a potent and selective 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors).
Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antipark...
WAY 181187 oxalate
WAY 181187 oxalate is a selective and high affinity 5-HT6 agonist with 60-fold selectivity over other 5-HT and monoamine receptors.
RS 39604 hydrochloride
RS 39604 is a high affinity and selective 5-HT4 receptor antagonist that is orally active and long-lasting in vivo, with a pKi of 9.1 at 5-HT4 receptors in guin...
NAD 299 hydrochloride
NAD 299 hydrochloride is a 5-HT1A receptor antagonist. It can be used in psychotropic drug development.
(±)-LY 426965 dihydrochloride
(±)-LY 426965 dihydrochloride is a selective 5-HT1A antagonist.
Alverine Citrate is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.
Sarpogrelate is a drug under the development of Mitsubishi Chemical as 5HT2A and 5-HT2B receptor. antagonists. It is used as an antiplatelet agent and has been ...