MK0873 - CAS 500355-52-2
Catalog number:
500355-52-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H18N4O3
Molecular Weight:
422.44
COA:
Inquire
Targets:
PDE4
Description:
MK0873 is a phosphodiesterase 4 (PDE4) inhibitor. It has shown as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans along with a minipig skin biopsy model. It was developed by Merck. It was used to treat rheumatoid arthritis in phase II clinical trials and plaque psoriasis in phase I clinical trials, but it has no recent research progress.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
N-cyclopropyl-1-[3-[2-(1-oxidopyridin-1-ium-3-yl)ethynyl]phenyl]-4-oxo-1,8-naphthyridine-3-carboxamide;MK-0873;3-((3-(3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)phenyl)ethynyl)pyridine 1-oxide
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
MK0873 was used to treat rheumatoid arthritis and plaque psoriasis.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
772.1±60.0 °C | Condition: Press: 760 Torr
Density:
1.34±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
JJWKQXNHYDJXKF-UHFFFAOYSA-N
InChI:
InChI=1S/C25H18N4O3/c30-23-21-7-2-12-26-24(21)29(16-22(23)25(31)27-19-10-11-19)20-6-1-4-17(14-20)8-9-18-5-3-13-28(32)15-18/h1-7,12-16,19H,10-11H2,(H,27,31)
Canonical SMILES:
C1CC1NC(=O)C2=CN(C3=C(C2=O)C=CC=N3)C4=CC=CC(=C4)C#CC5=C[N+](=CC=C5)[O-]
Current Developer:
MK0873 was developed by Merck. It was used to treat rheumatoid arthritis in phase II clinical trials and plaque psoriasis in phase I clinical trials, but it has no recent research progress.
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