MK-7145 - CAS 1255204-84-2
Catalog number: 1255204-84-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H30N2O6
Molecular Weight:
466.53
COA:
Inquire
Targets:
Potassium Channel
Description:
This active molecular is a selective renal outer medullary potassium channel (RMOK) inhibitor originated by Merck Sharp & Dohme for the treatment of hypertension and heart failure. RMOK is an ATP-dependent potassium channel that transports potassium out of cells. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 with IC50 value > 30 μM. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. But in Feb 2015, Merck terminated a phase I trial in Hypertension in Australia and New Zealand.
Purity:
98%
Appearance:
Powder
Synonyms:
5,5'-((1R,1'R)-piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one);1255204-85-3 (2HCl)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
hypertension and heart failure
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
OCKGFTQIICXDQW-ZEQRLZLVSA-N
InChI:
1S/C26H30N2O6/c1-15-17(3-5-19-21(15)13-33-25(19)31)23(29)11-27-7-9-28(10-8-27)12-24(30)18-4-6-20-22(16(18)2)14-34-26(20)32/h3-6,23-24,29-30H,7-14H2,1-2H3/t23-,24-/m0/s1
Canonical SMILES:
Cc1c(ccc2c1COC2=O)[C@H](CN3CCN(CC3)C[C@@H](c4ccc5c(c4C)COC5=O)O)O
Current Developer:
Originator: Merck Sharp & Dohme
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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