MK-7145 - CAS 1255204-84-2
Catalog number: 1255204-84-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H30N2O6
Molecular Weight:
466.53
COA:
Inquire
Targets:
Potassium Channel
Description:
This active molecular is a selective renal outer medullary potassium channel (RMOK) inhibitor originated by Merck Sharp & Dohme for the treatment of hypertension and heart failure. RMOK is an ATP-dependent potassium channel that transports potassium out of cells. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 with IC50 value > 30 μM. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. But in Feb 2015, Merck terminated a phase I trial in Hypertension in Australia and New Zealand.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
5,5'-((1R,1'R)-piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one);1255204-85-3 (2HCl)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
hypertension and heart failure
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
OCKGFTQIICXDQW-ZEQRLZLVSA-N
InChI:
1S/C26H30N2O6/c1-15-17(3-5-19-21(15)13-33-25(19)31)23(29)11-27-7-9-28(10-8-27)12-24(30)18-4-6-20-22(16(18)2)14-34-26(20)32/h3-6,23-24,29-30H,7-14H2,1-2H3/t23-,24-/m0/s1
Canonical SMILES:
Cc1c(ccc2c1COC2=O)[C@H](CN3CCN(CC3)C[C@@H](c4ccc5c(c4C)COC5=O)O)O
Current Developer:
Originator: Merck Sharp & Dohme
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Potassium Channel Products


CAS 166095-21-2 BMS-191095

BMS-191095
(CAS: 166095-21-2)

BMS-191095 is an activators that has selective effects on mitochondrial ATP-sensitive potassium (mitoKATP) channels. in vitro: induces mitochondrial-depolarizat...

GYKI-16638
(CAS: 778564-77-5)

GYKI-16638 is Potassium channel and Sodium channel antagonist originated by Nonindustrial source. It is a novel antiarrhythmic agent.

CAS 184653-84-7 Carabersat

Carabersat
(CAS: 184653-84-7)

Carabersat, also called as SB 204269, an orally-effective anticonvulsant agent, is an ATP-sensitive potassium channel (K-ATP) opener with potential effect to t...

CAS 7081-53-0 Doxapram HCl

Doxapram HCl
(CAS: 7081-53-0)

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

CAS 364-98-7 Diazoxide

Diazoxide
(CAS: 364-98-7)

Diazoxide is a benzothiadiazine derivative which acts as a potassium channel activator.

CAS 309-29-5 Doxapram

Doxapram
(CAS: 309-29-5)

Doxapram is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chem...

CAS 21187-98-4 Gliclazide

Gliclazide
(CAS: 21187-98-4)

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

Celikalim
(CAS: 124916-54-7)

Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical tri...

RPR-260243
(CAS: 668463-35-2)

RPR-260243 is a selective activator of the Human Ether-ago-go-Related Gene (hERG) (IC50 = 58 nM).

CAS 134017-78-0 U89232

U89232
(CAS: 134017-78-0)

U89232, a cardioselective cyanoguanidine analog of cromakalim, appears to be a cardioselective KATP channel opener.

CAS 36167-63-2 Halofantrine Hydrochloride

Halofantrine Hydrochloride
(CAS: 36167-63-2)

Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel used to treat malaria.

CAS 202821-81-6 BMS 191011

BMS 191011
(CAS: 202821-81-6)

BMS 191011 is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It is neuroprotectant in two distinct animal models of stroke...

CAS 522-51-0 Dequalinium Chloride

Dequalinium Chloride
(CAS: 522-51-0)

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.

CAS 152802-84-1 KRN4884

KRN4884
(CAS: 152802-84-1)

KRN4884, a synthesized 3-pyridine derivative, shows a long-lasting antihypertensive effect based on its potent potassium channel-opening action. The long-lastin...

ML252
(CAS: 1392494-64-2)

ML252 is a selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM) used in vivo to study KCNQ2 pharmocology.

NS 1619
(CAS: 153587-01-0)

NS 1619, a benzimidazalone derivative, activates BKca channels in a number of tissues. However, the effect of NS 1619 was dependent upon the presence of Ca 2+ i...

CAS 75507-68-5 Flupirtine maleate

Flupirtine maleate
(CAS: 75507-68-5)

Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also ...

CAS 33400-45-2 Flupirtine Hydrochloride

Flupirtine Hydrochloride
(CAS: 33400-45-2)

Flupirtine is an agonist of Kv7 potassium (KCNQ) channels, doubles channel currents when applied at 10 µM.

CAS 220641-11-2 Naminidil

Naminidil
(CAS: 220641-11-2)

Naminidil is an ATP-Sensitive Potassium Channel Vasodilator used for the treatment of Alopecia.

CAS 928774-43-0 PF-3716556

PF-3716556
(CAS: 928774-43-0)

PF 3716556 is a potent and selective P-CAB with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, r...

Quick Inquiry

Verification code

Featured Items