MK-7145 - CAS 1255204-84-2
Catalog number: 1255204-84-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Potassium Channel
This active molecular is a selective renal outer medullary potassium channel (RMOK) inhibitor originated by Merck Sharp & Dohme for the treatment of hypertension and heart failure. RMOK is an ATP-dependent potassium channel that transports potassium out of cells. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 with IC50 value > 30 μM. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. But in Feb 2015, Merck terminated a phase I trial in Hypertension in Australia and New Zealand.
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5,5'-((1R,1'R)-piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one);1255204-85-3 (2HCl)
Soluble in DMSO
-20°C Freezer
hypertension and heart failure
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Canonical SMILES:
Current Developer:
Originator: Merck Sharp & Dohme
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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