MK-6892 - CAS 917910-45-3
Catalog number: 917910-45-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H22N4O5
Molecular Weight:
386.4
COA:
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Targets:
GPR109A
Description:
MK-6892 is a highly potential GPR109A agonist.
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Purity:
>98%
MSDS:
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1.Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Shen HC1, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL. J Med Chem. 2010 Mar 25;53(6):2666-70. doi: 10.1021/jm100022r.
Biaryl cyclohexene carboxylic acids were discovered as full and potent niacin receptor (GPR109A) agonists. Compound 1e (MK-6892) displayed excellent receptor activity, good PK across species, remarkably clean off-target profiles, good ancillary pharmacology, and superior therapeutic window over niacin regarding the FFA reduction versus vasodilation in rats and dogs.
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CAS 917910-45-3 MK-6892

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