MK-5172 - CAS 1350514-68-9
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 after a p.o. 1 mg/kg dose.
Publictions citing BOC Sciences Products
  • >> More
Related CAS:
1350514-68-9 (free); 1350462-55-3 (hydrate)
Solid powder
(33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide; MK-5172; MK 5172; MK5172; Grazoprevir trade name: Zepatier‎
Canonical SMILES:
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HCV Products

CAS 1350462-55-3 MK-5172 hydrate

MK-5172 hydrate
(CAS: 1350462-55-3)

In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical stu...

CAS 1256388-51-8 Ledipasvir

(CAS: 1256388-51-8)

Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.

(CAS: 1258226-87-7)

Ombitasvir, a NS5A inhibitor, could be effective in the treatment of HCV as an antiviral agent. IC50: 14 pM and 5 pM (EC50) for genotype 1a-H77 and 1b-Con1 resp...

CAS 958002-33-0 Beclabuvir

(CAS: 958002-33-0)

Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabu...

(CAS: 263870-19-5)

APC-6336 is a Hepatitis C virus NS3 protein inhibitor.

CAS 817204-33-4 PSI-6130

(CAS: 817204-33-4)

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase. It is metabolized to two pharmacologically active species in primary human hepatocytes.


GSK-2818713 is a second-generation inhibitor of hepatitis C virus (HCV) NS5A replication. Compared to daclatasvir, a first-generation NS5A replication complex i...

CAS 1009119-64-5 Daclatasvir

(CAS: 1009119-64-5)

Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).

CAS 1502654-87-6 Ledipasvir D-tartrate

Ledipasvir D-tartrate
(CAS: 1502654-87-6)

Against JFH1/3a-NS5A, DCV was more potent (EC(50) = 0.52 nM) than GS-5885 (EC(50) = 141 nM). DCV sensitivity was increased against JFH1/3a-NS5A-M28V (EC50 = 0.0...

CAS 1200133-34-1 VCH-916

(CAS: 1200133-34-1)

VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for de...

(CAS: 870142-71-5)

ACH-806 is a Hepatitis C virus NS3 protein inhibitor. It can inhibit viral RNA replication in HCV replicon cells and is active in genotype 1 HCV-infected patien...

CAS 81485-25-8 Peretinoin

(CAS: 81485-25-8)

Peretinoin, also known as NIK-333, orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and acti...

(CAS: 1377049-84-7)

Velpatasvir is a selective Hepatitis C virus NS 5 protein inhibitor originated by Gilead Sciences. It has showed pan-genotypic activity and a high barrier to re...

CAS 923604-59-5 Simeprevir

(CAS: 923604-59-5)

Simeprevir plays an important role in HCV replication. Data from phase I and II clinical trials of TMC-435350 (TMC 435350; TMC 435; TMC-435350) to date have sho...

CAS 63968-64-9 Artemisinin

(CAS: 63968-64-9)

Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria.

CAS 691852-58-1 Nesbuvir

(CAS: 691852-58-1)

Nesbuvir, a novel selective nonstructural protein 5B (NS5B) polymerase inhibitor, acts as candidate for HCV treatment. It was reduced across different isolates.

CAS 876708-03-1 RO-9187

(CAS: 876708-03-1)

RO-9187 is a potent inhibitor of HCV virus replication in the replicon system. It is excellent substrates for deoxycytidine kinase and were phosphorylated with ...

CAS 36791-04-5 Ribavirin

(CAS: 36791-04-5)

Ribavirin is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor.

CAS 1132935-63-7 dasabuvir

(CAS: 1132935-63-7)

Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replica...

CAS 1009119-65-6 Daclatasvir dihydrochloride

Daclatasvir dihydrochloride
(CAS: 1009119-65-6)

Daclatasvir dihydrochloride is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype...

Chemical Structure

CAS 1350514-68-9 MK-5172

Quick Inquiry

Verification code

Featured Items