MK-4827 hydrochloride - CAS 1038915-64-8
Catalog number: 1038915-64-8
Category: Inhibitor
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Molecular Formula:
C19H21ClN4O
Molecular Weight:
356.85
COA:
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Targets:
PARP
Description:
MK-4827 HCl is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. It has a great activity in cancer cells with mutant BRCA-1 and BRCA-2, >330-fold selective against PARP3, V-PARP and Tank1.
Purity:
>98%
Related CAS:
1613220-15-7 (tosylate hydrate)
Appearance:
Light yellow solid powder
Synonyms:
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride; MK4827; MK 4827; MK4827; Niraparib; Niraparib HCl; Niraparib hydrochloride
MSDS:
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InChIKey:
YXYDNYFWAFBCAN-PFEQFJNWSA-N
InChI:
1S/C19H20N4O.ClH/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);1H/t14-;/m1./s1
Canonical SMILES:
O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N.[H]Cl
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CAS 1038915-64-8 MK-4827 hydrochloride

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