|Description||MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension. It has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase.|
|Synonyms||Alpha-Methyldopa hydrochloride;L-(-)-A-Methyldopa hydrochloride;Alpha-Methyldopa HCl;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;3-Hydroxy-alpha-methyl-L-tyrosine hydrochloride;L-Tyrosine, 3-hydroxy-alpha-methyl-, hydrochloride;Methyldopa hydrochloride|
|Solubility||10 mM in DMSO|
|Application||MK-351 hydrochloride is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||441.6°C at 760 mmHg|
Zoleprodolol, an oxadiazol derivative, has been found to be an adrenergic receptor antagonist.
Phenylephrine HCl is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, a...
Pindolol, an Indole derivative, could be used in the treatment of hypertension and arrhythmia for acting as a 5-HT1A/1B receptor antagonist. IC50: 33nM(Ki).
BMS-196085, a sulfanilamide derivative, has been found to be a β-adrenergic receptor agonist that was once studied in obesity as well as yype 2 diabetes mellitu...
Guanadrel, as an antihypertensive agent, is an orally active postganglionic sympathetic inhibitor.
AR-08 is an agonist of α2-adrenergic receptor undergone in phase II clinical trials by Arbor Pharmaceuticals for the treatment of attention deficit and hyperac...
An S enantiomer which has affinity at alpha 1 adrenergic receptor
Fenoterol, a phenol derivative, is a β2-adrenoceptor agonist and could be used as a bronchodilator and an antiasthmatic.
Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respe...
Carvedilol phosphate hemihydrate is a nonselective beta (β1, β2) blocker and alpha (α1) blocker, inhibits LDL oxidation (IC50 = 3.8 μM).
Yohimbine, an indolalkylamine alkaloid, blocks presynaptic alpha-2 adrenergic receptors. IC50= 0.6 μM Ki: 1.05 nM, alphaα2Areceptor
Landiolol is an ultra-short-acting Beta 1 adrenergic receptor antagonist using for managing supraventricular tachyarrhythmias in sepsis. It is also used as an a...
Terazosin is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH).
Propranolol Hydrochloride is a β-adrenergic antagonist used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary h...
Salbutamol Sulfate is a Non-selective 2-adrenergic receptor agonist (IC50=8.93 µM)
Metoprolol is a a selective β1 receptor blocker for the treatment of a variety of cardiovascular disorder.
Carmoterol, a quinolin derivative, has been found to a β2-adrenoceptor agonist that could be an effective bronchodilating agent.
Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 a...
CGP-12388 is a beta-adrenoceptor antagonist-derived radioligands. It is used for cardiac PET imaging due to its high hydrophilicity and affinity to beta-adrenoc...
Pronethalol is a non-selective beta-adrenergic blocking agentused in treatment due to carcinogenic properties.