MK-2894 Na salt - CAS 1006036-88-9
Catalog number:
1006036-88-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H21F3NNaO3S
Molecular Weight:
495.49
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
The sodium salt form of MK-2894 that is found to have conceivable potency and selectivity for further study and might be safer than traditional Non-steroidal anti-inflammatory drugs and coxibs in the treatment of pain and inflammation. IC50: 2.5 nM (Ki=0.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
Powder
Synonyms:
sodium;4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoate;MK-2894(sodiumsalt);1006036-88-9;MK-2894Nasalt;C25H21F3NO3S.Na
Solubility:
10 mM in DMSO
Storage:
-20 ºC Freeze
MSDS:
Inquire
Application:
The sodium salt form of MK-2894 that is found to have conceivable potency and selectivity in the treatment of pain and inflammation.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
RQRUUNKVGDVBFV-UHFFFAOYSA-M
InChI:
InChI=1S/C25H22F3NO3S.Na/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32;/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32);/q;+1/p-1
Canonical SMILES:
CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)[O-])CC4=CC=C(C=C4)C(F)(F)F.[Na+]
Current Developer:
Merck
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Prostaglandin Receptor Products


CAS 402473-54-5 ONO-AE3-208

ONO-AE3-208
(CAS: 402473-54-5)

ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, a...

CAS 62561-03-9 (+)-Cloprostenol sodium salt

(+)-Cloprostenol sodium salt
(CAS: 62561-03-9)

(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used ...

PF-04418948
(CAS: 1078166-57-0)

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PG...

CAS 847728-01-2 CJ-42794

CJ-42794
(CAS: 847728-01-2)

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It ...

CAS 143443-90-7 Ifetroban

Ifetroban
(CAS: 143443-90-7)

Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials f...

CAS 155206-00-1 Bimatoprost

Bimatoprost
(CAS: 155206-00-1)

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

GSK-345931A
(CAS: 869534-13-4)

GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.

CAS 415903-37-6 Grapiprant (CJ-023423)

Grapiprant (CJ-023423)
(CAS: 415903-37-6)

Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic prop...

CAS 851204-35-8 EP1-antanoist-1

EP1-antanoist-1
(CAS: 851204-35-8)

A EP1 antagonist (pKi= 7.54) (pIC50= 8.5)

CAS 78919-13-8 Iloprost

Iloprost
(CAS: 78919-13-8)

Iloprost is a drug used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels are cons...

CAS 1006036-87-8 MK-2894

MK-2894
(CAS: 1006036-87-8)

MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor. It is found to have conceivable potency and selectivity for...

CAS 851723-84-7 OC000459

OC000459
(CAS: 851723-84-7)

OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.

PF-4217329
(CAS: 1005549-94-9)

PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well t...

CAS 752187-80-7 CP 544326

CP 544326
(CAS: 752187-80-7)

CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug...

CAS 2624-44-4 Ethamsylate

Ethamsylate
(CAS: 2624-44-4)

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhe...

CAS 72814-32-5 BW 245C

BW 245C
(CAS: 72814-32-5)

BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1)agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding ...

CAS 59122-46-2 Misoprostol

Misoprostol
(CAS: 59122-46-2)

Misoprostol, a synthetic analog of natural prostaglandin E1, is an effective anti-ulcer agent and also has oxytocic properties.

AM-211 sodium
(CAS: 1263077-74-2)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

CAS 1006036-88-9 MK-2894 Na salt

MK-2894 Na salt
(CAS: 1006036-88-9)

The sodium salt form of MK-2894 that is found to have conceivable potency and selectivity for further study and might be safer than traditional Non-steroidal an...

CAS 1175526-27-8 AM-211

AM-211
(CAS: 1175526-27-8)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

Chemical Structure

CAS 1006036-88-9 MK-2894 Na salt

Quick Inquiry

Verification code

Featured Items