MK-2894 - CAS 1006036-87-8
Catalog number:
1006036-87-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H22F3NO3S
Molecular Weight:
473.51
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor. It is found to have conceivable potency and selectivity for further study and might be safer than traditional Non-steroidal anti-inflammatory drugs and co
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Purity:
95%
Appearance:
Powder
Synonyms:
MK-2894;CHEMBL597997;1006036-87-8;4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoicacid;C25H22F3NO3S;GTPL4041
Solubility:
10 mM in DMSO
Storage:
-20 ºC Freeze
MSDS:
Inquire
Application:
MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
QJZQFVRFJCGDKF-UHFFFAOYSA-N
InChI:
InChI=1S/C25H22F3NO3S/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32)
Canonical SMILES:
CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
Current Developer:
Merck
1.The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Blouin M1, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, Lévesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O'Neill G, Ducharme Y, Friesen R. J Med Chem. 2010 Mar 11;53(5):2227-38. doi: 10.1021/jm901771h.
The discovery of highly potent and selective second generation EP(4) antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.
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CAS 1006036-87-8 MK-2894

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