|Molecular Formula||C33 H27 F4 N3 O4|
|Description||MK-0893 is a selective glucagon receptor antagonist. It can block glucagon binding to the human GCGR and antagonize glucagon-induced intracellular accumulation of cAMP with nanomolar potency. MK-0893 has strong antihyperglycemic efficacy in preclinical models and prominent effects on hepatic gene-expression related to amino acid metabolism. But Phase-II clinical trials in Type-2 diabetes mellitus were discontinued.|
|Solubility||Soluble in DMSO|
|Application||Type 2 diabetes mellitus|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator Merck & Co|
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