MK 0343 - CAS 233275-76-8
Catalog number: 233275-76-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H17F2N7O
Molecular Weight:
397.38
COA:
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Targets:
GABA Receptor
Description:
MK 0343, also known as MRK-409, is a subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively). MK-0343 is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
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Purity:
>98%
Appearance:
Off-white solid
Synonyms:
7-cyclobutyl-3-(2,6-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine; MK-0343; MK 0343; MK0343; MRK 409; MRK409; MRK-409
MSDS:
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InChIKey:
GOIFCXRIFSYPFG-UHFFFAOYSA-N
InChI:
1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3
Canonical SMILES:
CN1C(=NC=N1)COC2=NN3C(=NN=C3C4=C(C=CC=C4F)F)C=C2C5CCC5
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