Mitoxantrone - CAS 65271-80-9
Catalog number: 65271-80-9
Category: Inhibitor
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Molecular Formula:
C22H28N4O6
Molecular Weight:
444.48
COA:
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Targets:
Topoisomerase
Description:
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma.
Purity:
>98%
MSDS:
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InChIKey:
KKZJGLLVHKMTCM-UHFFFAOYSA-N
InChI:
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
Canonical SMILES:
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
1.Induction of multixenobiotic defense mechanisms in resistant Daphnia magna clones as a general cellular response to stress.
Jordão R1, Campos B2, Lemos MF3, Soares AM4, Tauler R2, Barata C5. Aquat Toxicol. 2016 Mar 16;175:132-143. doi: 10.1016/j.aquatox.2016.03.015. [Epub ahead of print]
Multixenobiotic resistance mechanisms (MXR) were recently identified in Daphnia magna. Previous results characterized gene transcripts of genes encoding and efflux activities of four putative ABCB1 and ABCC transporters that were chemically induced but showed low specificity against model transporter substrates and inhibitors, thus preventing us from distinguishing between activities of different efflux transporter types. In this study we report on the specificity of induction of ABC transporters and of the stress protein hsp70 in clones selected to be genetically resistant to ABCB1 chemical substrates. Clones resistant to mitoxantrone, ivermectin and pentachlorophenol showed distinctive transcriptional responses of transporter protein coding genes and of putative transporter dye activities. Expression of hsp70 proteins also varied across resistant clones. Clones resistant to mitoxantrone and pentachlorophenol showed high constitutive levels of hsp70.
2.Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold.
Kim TE1, Kim CG1, Kim JS2, Jin S2, Yoon S3, Bae HR4, Kim JH5, Jeong YH5, Kwak JY1. Int J Nanomedicine. 2016 Mar 2;11:823-35. doi: 10.2147/IJN.S101846. eCollection 2016.
An artificial three-dimensional (3D) culture system that mimics the tumor microenvironment in vitro is an essential tool for investigating the cross-talk between immune and cancer cells in tumors. In this study, we developed a 3D culture system using an electrospun poly(ε-caprolactone) (PCL) nanofibrous scaffold (NFS). A hybrid NFS containing an uninterrupted network of nano- and submicron-scale fibers (400 nm to 2 µm) was generated by deposition onto a stainless steel mesh instead of an aluminum plate. The hybrid NFS contained multiplanar pores in a 3D structure. Surface-seeded mouse CT26 colon cancer cells and bone marrow-derived dendritic cells (BM-DCs) were able to infiltrate the hybrid NFS within several hours. BM-DCs cultured on PCL nanofibers showed a baseline inactive form, and lipopolysaccharide (LPS)-activated BM-DCs showed increased expression of CD86 and major histocompatibility complex Class II. Actin and phosphorylated FAK were enriched where unstimulated and LPS-stimulated BM-DCs contacted the fibers in the 3D hybrid NFS.
3.Clarification to provide further understanding of the conduct and design of TROPIC: A Phase 3 trial of cabazitaxel versus mitoxantrone in patients with metastatic castration-resistant prostate cancer.
De Bono J1, Shen L, Sartor O. Arch Ital Urol Androl. 2016 Mar 31;88(1):72-73. doi: 10.4081/aiua.2016.1.72.
Not available.
4.Reply to: Clarification to provide further understanding of the conduct and design of TROPIC: A Phase 3 trial of cabazitaxel versus mitoxantrone in patients with metastatic castration-resistant prostate cancer.
Perletti G1. Arch Ital Urol Androl. 2016 Mar 31;88(1):74-75. doi: 10.4081/aiua.2016.1.74.
Not available.
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CAS 65271-80-9 Mitoxantrone

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