Mitoguazone - CAS 459-86-9
Catalog number:
459-86-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.
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Synonyms:
MeGAG; methyl-G; methyl-GAG; MGBG; MGGH; DRG-0223; NSC32946
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CAS 459-86-9 Mitoguazone

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