|Description||MitoE10, a mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker, was synthesised starting from 1-hydroxy-11-dodecyne, obtained by the addition of 1-bromononane to lithiated propargyl THP ether followed by triple bond migration using NaH and ethylenediamine. Preliminary biological data demonstrate that MitoE10 shows greater efficacy in preventing lipid peroxidation, mitochondrial oxidative damage and damage to mitochondrial DNA than non-targeted compounds.|
|Related CAS||1810703-64-0 (mesylate salt); 1810703-63-9 (cation)|
|Synonyms||(10-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)decyl)triphenylphosphonium methanesulfonate; MitoE10; Mito E10; MitoE-10; Vitaman E-triphenylphosphonium conjugate; 1810703-64-0 (mesylate salt); 1810703-63-9 (cation)|
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