Mirk-IN-1 - CAS 1386979-55-0
Catalog number:
1386979-55-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H17Cl2N5O4
Molecular Weight:
498.32
COA:
Inquire
Targets:
DYRK
Description:
Mirk-IN-1, a pyrido[2,3-d]pyrimidine derivative, has been found to be a DYRK1A/B inhibitor and probably have antitumor activity through influencing the accumulation and induce the DNA damage and apoptosis of Panc1 in tumor cells. IC50: 68±48/22±8 nM (Dyrk
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Purity:
98%
Appearance:
Powder
Synonyms:
Mirk-IN-1; CHEMBL3094448; SCHEMBL10446906; CQKBSRPVZZLCJE-UHFFFAOYSA-N; BDBM50444379; AKOS025147328; N-[2-chloro-5-[(3-chlorophenyl)methylcarbamoyl]phenyl]-2-methoxy-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxamide
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Mirk-IN-1 has been found to be a DYRK1A/B inhibitor and probably have antitumor activity through influencing the accumulation and induce the DNA damage and apoptosis of Panc1 in tumor cells.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
CQKBSRPVZZLCJE-UHFFFAOYSA-N
InChI:
InChI=1S/C23H17Cl2N5O4/c1-34-23-27-11-14-8-16(22(33)29-19(14)30-23)21(32)28-18-9-13(5-6-17(18)25)20(31)26-10-12-3-2-4-15(24)7-12/h2-9,11H,10H2,1H3,(H,26,31)(H,28,32)(H,27,29,30,33)
Canonical SMILES:
COC1=NC=C2C=C(C(=O)NC2=N1)C(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC(=CC=C4)Cl)Cl
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