Minoxidil - CAS 38304-91-5
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Potassium Channel
Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth.
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1.Doppler laser imaging predicts response to topical minoxidil in the treatment of female pattern hair loss.
McCoy J1, Kovacevic M2, Situm M3, Stanimirovic A4, Bolanca Z3, Goren A5. J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):131-4.
Topical minoxidil is the only drug approved by the US FDA for the treatment of female pattern hair loss. Unfortunately, following 16 weeks of daily application, less than 40% of patients regrow hair. Several studies have demonstrated that sulfotransferase enzyme activity in plucked hair follicles predicts topical minoxidil response in female pattern hair loss patients. However, due to patients’ discomfort with the procedure, and the time required to perform the enzymatic assay it would be ideal to develop a rapid, non-invasive test for sulfotransferase enzyme activity. Minoxidil is a pro-drug converted to its active form, minoxidil sulfate, by sulfotransferase enzymes in the outer root sheath of hair. Minoxidil sulfate is the active form required for both the promotion of hair regrowth and the vasodilatory effects of minoxidil. We thus hypothesized that laser Doppler velocimetry measurement of scalp blood perfusion subsequent to the application of topical minoxidil would correlate with sulfotransferase enzyme activity in plucked hair follicles.
2.Infantile generalized hypertrichosis caused by topical minoxidil.
Rampon G1, Henkin C1, Souza PR1, Almeida HL Jr2. An Bras Dermatol. 2016 Feb;91(1):87-8. doi: 10.1590/abd1806-4841.20164010.
Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children.
3.Evaluation of a method utilizing PhysioFlow®, a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beagle.
Payseur JD1, Rigney JJ1, Turner SL1, Wu X1, Murphy DJ1, Rossman EI1. J Pharmacol Toxicol Methods. 2016 Apr 2. pii: S1056-8719(16)30018-1. doi: 10.1016/j.vascn.2016.03.007. [Epub ahead of print]
INTRODUCTION: Currently, standard methods for measuring cardiac output are either invasive (i.e. flow probe) or are limited in terms of short measurement intervals and measurement variability (i.e. echocardiography). The ability to reliably measure cardiac output in a non-invasive manner in large animals would provide a valuable tool to expand functional cardiovascular endpoints in preclinical safety studies. PhysioFlow® is a novel method that uses waveform analysis of an impedance signal to measure cardiac output non-invasively. Unlike cardiac impedance techniques in the past, PhysioFlow® is not dependant on thoracic structure or basal thoracic impedance (Z0) and therefore this methodology is transferrable from human to animal models.
4.The Success of Thread-embedding Therapy in Generating Hair Re-growth in Mice Points to Its Possibly Having a Similar Effect in Humans.
Shin HJ1, Lee DJ2, Kwon K2, Seo HS2, Jeong HS3, Lee JY3, Ha KT3, Lee CH4, Jang YS5, Lee BW6, Kim BJ7, Jung MH7. J Pharmacopuncture. 2015 Dec;18(4):20-5. doi: 10.3831/KPI.2015.18.033.
OBJECTIVES: Recently, thread-embedding therapy (TET) has been widely applied in Korean medicine for cosmetic purposes such as reducing skin wrinkles. An inserted thread was reported to have induced continuous stimulation, followed by support for connective tissue regeneration. However, the potential role of TET in hairgrowth has not yet been reported.
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CAS 38304-91-5 Minoxidil

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