Milrinone - CAS 78415-72-2
Catalog number:
B0084-291905
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H9N3O
Molecular Weight:
211.22
COA:
Inquire
Targets:
Phosphodiesterase (PDE)
Description:
Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with vasodilator properties, used to increase the heart's contractility. It increases erythrocyte cAMP activity via inhibiting erythrocyte phosphodiesterase.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-291905 1 g $268 In stock
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Brife Description:
phosphodiesterase 3 (PDE3) inhibitor, vasodilator agent
Purity:
>98%
Synonyms:
Primacor; Corotrope; Corotrop; Milrinona
Solubility:
Slightly soluble
MSDS:
Inquire
Application:
increase the heart's contractility
Melting Point:
> 300 °C
InChIKey:
PZRHRDRVRGEVNW-UHFFFAOYSA-N
InChI:
InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
Canonical SMILES:
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
1.Milrinone use for hemodynamic instability in patent ductus arteriosus ligation.
Halliday M1, Kavarana M2, Ebeling M1, Kiger J1. J Matern Fetal Neonatal Med. 2016 Apr 12:1-15. [Epub ahead of print]
OBJECTIVE: Determine if prophylactic milrinone improves cardiovascular or long term clinical outcomes in preterm neonates who receive surgical PDA ligation.
2.Milrinone in Enterovirus 71 Brain Stem Encephalitis.
Wang SM1. Front Pharmacol. 2016 Mar 29;7:82. doi: 10.3389/fphar.2016.00082. eCollection 2016.
Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotropic agents, milrinone is selected as a therapeutic agent for EV71- induced PE due to its immunopathogenesis. Milrinone is a type III phosphodiesterase inhibitor that has both inotropic and vasodilator effects. Its clinical efficacy has been shown by modulating inflammation, reducing sympathetic over-activity, and improving survival in patients with EV71-associated PE. Milrinone exhibits immunoregulatory and anti-inflammatory effects in the management of systemic inflammatory responses in severe EV71 infection.
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CAS 78415-72-2 Milrinone

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