Milbemycin Oxime - CAS 129496-10-2
Catalog number:
B0084-474453
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
2C32H45NO7.2C31H43NO7
Molecular Weight:
2194.78
COA:
Inquire
Targets:
Antiparasitic
Description:
Milbemycin oxime, a mixture of Milbemycin Oxime A3 and A4, is an antiparasitic and could be effectively used as an veterinary drug.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-474453 500 mg $398 In stock
B0084-474453 1 g $498 In stock
B0084-474453 5 g $998 In stock
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Purity:
≥ 98.0%
Appearance:
White powder
Synonyms:
Milbemycin A 5-oxime; Milbemite; Trifexis; Milbemycin oxime; Interceptor; Milbe Mite
Solubility:
Soluble in DMSO(35 mg/mL), not in water
Storage:
Store at temperature below –20ºC, preserve in tight containers and avoid excessive light.
MSDS:
Inquire
Application:
Milbemycin oxime is an antiparasitic and could be effectively used as an veterinary drug.
Quality Standard:
In-house Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
CKVMAPHTVCTEMM-UHFFFAOYSA-N
InChI:
1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-1
Canonical SMILES:
CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)C.CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)OC1C
1.Lungworm disease in cats: ABCD guidelines on prevention and management.
Pennisi MG, Hartmann K, Addie DD, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Horzinek MC, Hosie MJ, Lloret A, Lutz H, Marsilio F, Radford AD, Thiry E, Truyen U, Möstl K; European Advisory Board on Cat Diseases. J Feline Med Surg. 2015 Jul;17(7):626-36. doi: 10.1177/1098612X15588455.
OVERVIEW: Cardiopulmonary nematodes are emerging parasites of cats in Europe. A number of helminth parasites may be involved. The most prevalent lungworm in domestic cats is Aelurostrongylus abstrusus. Oslerus rostratus and Troglostrongylus species are found mainly in wild cats. The trichurid Capillaria aerophila has a low host specificity and is not uncommon in cats. Additionally the lung flukes Paragonimus species are reported in many species outside of Europe, including cats.
2.Efficacy of oral afoxolaner plus milbemycin oxime chewables against induced infestations with Dermacentor reticulatus in dogs.
Rehbein S1, Fourie JJ2, de Vos C2, Anderson A3, Larsen DL3, Jeannin P4. Parasitol Res. 2016 Jan 27. [Epub ahead of print]
The efficacy of afoxolaner plus milbemycin oxime (AFX + MO) combination chewables (NexGard Spectra®, Merial) and AFX single-entity chewables (NexGard®, Merial) against induced infestations with Dermacentor reticulatus ticks was evaluated in dogs. Thirty dogs were assigned to blocks of three animals each based on pre-allocation tick counts and were randomly allocated to one of three groups: untreated (control), treated with a combination of AFX + MO chewables to be as close as possible to the minimum effective dose of AFX + MO (2.5 + 0.5 mg per kg body weight), and treated with a combination of NexGard® chewables to be as close as possible to the minimum effective dose of AFX (2.5 mg per kg body weight). Treatments were administered orally once on day 0. Starting 2 days before treatment administration, each dog was infested with approximately 50 ticks weekly for six consecutive weeks. Live ticks were counted at ∼48 h post-treatment (removal count) and at ∼48 h (in situ counts) and ∼72 h (removal counts) following each post-treatment infestation.
3.Efficacy of a single dose of milbemycin oxime/praziquantel combination tablets, Milpro(®), against adult Echinococcus multilocularis in dogs and both adult and immature E. multilocularis in young ca
Cvejic D1, Schneider C2, Fourie J3, de Vos C3, Bonneau S4, Bernachon N4, Hellmann K2. Parasitol Res. 2016 Mar;115(3):1195-202. doi: 10.1007/s00436-015-4855-7. Epub 2015 Dec 11.
Two single-site, laboratory, negatively controlled, masked, randomised dose confirmation studies were performed: one in dogs, the other in cats. After a period of acclimatisation, both the dogs and cats were orally infected with Echinococcus multilocularis protoscoleces. In the dog study, 10 dogs received a single dose of Milpro® tablets at a minimum dose of 0.5 mg/kg milbemycin oxime and 5 mg/kg praziquantel 18 days post-infection and 10 dogs received no treatment. In the cat study, 10 cats received a single dose of Milpro® tablets at a minimum dose of 2 mg/kg milbemycin oxime and 5 mg/kg praziquantel 7 days post-infection, 10 cats received a single dose of the treatment 18 days post-infection and 10 cats remained untreated. In both studies, intestinal worm counts were performed 23 days post-infection at necropsy. No worms were retrieved from any of the 30 treated animals. Nine of 10 control dogs had multiple worms (geometric mean 91, arithmetic mean 304) and all 10 control cats had multiple worms (geometric mean 216, arithmetic mean 481).
4.Selamectin Is the Avermectin with the Best Potential for Buruli Ulcer Treatment.
Scherr N1, Pluschke G1, Thompson CJ2, Ramón-García S2. PLoS Negl Trop Dis. 2015 Aug 13;9(8):e0003996. doi: 10.1371/journal.pntd.0003996. eCollection 2015.
A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical isolates of Mycobacterium ulcerans. Milbemycin oxime and selamectin were the most active drugs against M. ulcerans with MIC values from 2 to 8 μg/mL and 2 to 4 μg/mL, respectively. In contrast, ivermectin and moxidectin, which are both in clinical use, showed no significant activity (MIC> 32 μg/mL). Time-kill kinetic assays showed bactericidal activity of selamectin and in vitro pharmacodynamic studies demonstrated exposure-dependent activity. These data together with analyses of published pharmacokinetic information strongly suggest that selamectin is the most promising macrocyclic lactone for BU treatment.
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CAS 129496-10-2 Milbemycin Oxime

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