|Targets||Glucocorticoid Receptor | Progesterone Receptor|
|Description||Mifepristone is a progesterone receptor antagonist(IC50= 0.2 nM) and a glucocorticoid receptor antagonist(IC50= 2.6 nM). It is used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is a synthetic steroid compound used as a pharmaceutical. It has occasionally been used in refractory Cushing's Syndrome. It had no effect on HeLa cell proliferation inhibition rate during 24 and 48 hours (p > 0.05) in vitro. It can significantly enhance the inhibitory effect of cisplatin on HeLa cell line at low concentrations combined with cisplatin. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy, eliciting its action through the nuclear progesterone receptor (PR). It is used in combination with misoprostol for the oral induction of first trimester abortions. It promotes efficient binding of PR to hormone response elements (HRE) on DNA, but prevents transcriptional activation of the receptor. It induces growth arrest, caspase activation, and cell death in anti-estrogen-resistant breast cancer cells, which indicats the effectiveness of PR antagonism as a novel approach to treatment of select cancers. It was developed by Danco Laboratories.|
|Appearance||Yellow crystalline powder|
|Synonyms||RU-486; RU 486; RU486; C-1073; C 1073; C1073; C-1073; Brand name: Mifegyne;Mifepriston;Pictovir; Mifepristonum; Mifepristona; Corlux. 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;RU-38486;Estra-4,9-dien-3-one,11-[4-(dimethylamino)- phenyl]-17-hydroxy-17-(1-propynyl)-,(11a,- 17a)-;17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one;Mifeprex;Mifepristonum [Latin];11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on|
|Solubility||DMSO: ≥ 59 mg/mL|
|Application||Mifepristone is used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It has occasionally been used in refractory Cushing's Syndrome. It is used in combination with misoprostol for the oral induction of first trimester abortions. It induces growth arrest, caspase activation, and cell death in anti-estrogen-resistant breast cancer cells, which indicats the effectiveness of PR antagonism as a novel approach to treatment of select cancers.|
|Quality Standard||CP standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Kilogram to ton|
|Boiling Point||628.6±55.0 °C | Condition: Press: 760 Torr|
|Melting Point||150 °C|
|Density||1.18±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Mifepristone has been listed.|
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