|Description||Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).|
3PO, as a small molecule competitive inhibitor of HIF-1-induced PFKFB3 it has the potential to suppress tumor glucose metabolism and growth of non-small cell lu...
CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM), does not affect other NAD+-dependent dehydrogenases.
This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activatio...
RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 sh...
The hydrochloride salt form of Droxicainide, a piperidine derivative, has been found to be an potential antiarrhythmic agent.
NSC659000 is a potential antifungal agent. It is one of the 3-(3-methyl-5-isoxazolyl)-2-styrylquinazolin-4(3H)-ones derivatives that be synthesized for antifung...
R-(-)-Arundic Acid, also called as ONO 2506, is an astrocyte modulating agent which can treat neurodegenerative diseases including Alzheimer's disease and Parki...
Gemcabene is an orally available lipid-lowering small molecule designed to target known lipid metabolic pathways, as an adjunctive therapy to reduce LDL-C, hsCR...
SEW 2871 is a potent, cell-permeable and selective sphingosine-1-phosphate type 1 receptor agonist (EC50= 13 nM). SEW 2871 suppresses the immune response by dec...
Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topo...
Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
Deoxyadenosine is a substrate of bacterial methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase and a product inhibitor produced by radical SAM enz...
Y-29794 is an orally active, potent and specific non-peptide inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of...
This active molecular is a selective and potent NK(3) antagonist. It has a high affinity for recombinant human (pK(i) value 8.9) and native guinea pig (pK(i) va...
RSL3, a glutathione peroxidase 4 inhibitor, has been found to show selective response to tumor cells with oncogenic RAS.
FR-217840 is a matrix metalloproteinase inhibitor. It can suppress joint destruction. FR217840 may have potential as a novel anti-rheumatic drug.
BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (IC50 = 0.9 uM).
Buthionine Sulphoximine, also known as NSC-326231, is a potent and specific inhibitor of alpha-glutamyl cysteine synthetase.
Alverine, a phenpropamine derivative, has been found to be a smooth muscle relaxant that could be used to against the spasm of the stomach, intestines and womb.
Berbamine hydrochloride, a natural compound derived from the Berberis amurensis plant, might affect the transport of intracellular Ca(2+).