|Description||Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).|
Henagliflozin, a glucoside compound, has been found to be a sodium-glucose transporter 2 inhibitor that could probably be effective in hyperglycaemic. It is und...
PYR-6921is a useful intermediate for chemical synthesis of biologically molecules.
PXS 4728A is a VAP-1 (aka SSAO/AOC3) inhibitor with IC50 values 5 nM in the clinical trial for the treatment of non-alcoholic steatohepatitis (NASH). Studies sh...
Berbamine hydrochloride, a natural compound derived from the Berberis amurensis plant, might affect the transport of intracellular Ca(2+).
Pinoresinol Diglucoside, one of the major lignans with various pharmacological activities, is a sugar lignan which inhibits α-glucosidase in vitro.
CI-959 free acid
CI-959 free acid is an orally effective inhibitor of cellular activation in both in vitro and animal models. It has antiallergic and anti-inflammatory propertie...
RUSKI-201 dihydrochloride is a sonic hedgehog acyltransferase (HHAT) inhibitor (IC50 = 0.20 μM) devoid of off-target cytotoxicity, and quantitative whole-proteo...
Crotamiton is a general antipruritic agent for treating scabies.
Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.It is sold over-the-counter in th...
Nanterinone mesylate is the methyl sulfonate form of Nanterinone, which is a novel positive inotropic and balanced-type vasodilating drug partially based on pho...
PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
GSK-1268997 is one of a metabolite of Pazopanib which is a selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits an...
Xylose is a sugar first isolated from wood.
Diperodon hydrochloride is a local anaesthetics designated by chemical abstracts as 3-piperidino-1,2-propanediol dicarbanilate monohydrate.
Lotilaner is an insecticide and veterinary drug.
unifiram (DM-235) is a piperazine derived research chemical which has nootropic effects in animal studies with significantly higher potency than piracetam.
Lapaquistat acetate, also referred as TAK475, is a squalene synthase inhibitor. As a cholesterol-lowering drug, Lapaquistat acetate decreased plasma cholesterol...
Lometraline, an aminotetralin derivative, is a potential antidepressant and/or anxiolytic agent.
5-R-Rivaroxaban is the R-isomer of Rivaroxaban, which is a novel, oral, direct Factor Xa (FXa) inhibitor. It is useful for antithrombotic agent and is a promisi...
Ioforminol is a new low-osmolar dimeric radiographic contrast agent. It exhibits similar preclinical properties to other dimeric radiographic contrast media. It...