Micafungin Sodium - CAS 208538-73-2
Catalog number: B0084-461995
Category: Inhibitor
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Molecular Formula:
C56H70N9NaO23S
Molecular Weight:
1292.26
COA:
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Targets:
Antifungal
Description:
Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-461995 250 mg $449 In stock
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Purity:
>98%
Synonyms:
FK463 Sodium; FK 463 Sodium; FK-463 Sodium
MSDS:
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InChIKey:
KOOAFHGJVIVFMZ-WZPXRXMFSA-M
InChI:
InChI=1S/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+;/m0./s1
Canonical SMILES:
CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)[O-])O)O)C(CC(=O)N)O)C)O)O)O.[Na+]
1.Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant.
Piersigilli F1, Auriti C, Bersani I, Goffredo B, Bianco G, Savarese I, Dotta A. Pediatr Infect Dis J. 2014 Apr;33(4):419-20. doi: 10.1097/INF.0000000000000116.
So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.
2.Comparison of the antifungal activity of micafungin and amphotericin B against Candida tropicalis biofilms.
Marcos-Zambrano LJ1, Escribano P2, Bouza E3, Guinea J4. J Antimicrob Chemother. 2016 May 4. pii: dkw162. [Epub ahead of print]
OBJECTIVES: Candida tropicalis is the fourth most common cause of candidaemia in hospitalized patients and associated mortality is high. C. tropicalis frequently causes biofilm-related infections. Echinocandins and amphotericin B show potent in vitro activity against C. albicans biofilms, but their activity against C. tropicalis biofilms has received little attention.
3.Prediction of micafungin area under the curve data by using peak concentration: applicability and utility in antifungal therapy.
Srinivas NR1. Future Microbiol. 2016 Apr;11:485-90. doi: 10.2217/fmb.16.3. Epub 2016 Apr 12.
AIM: To describe a predictive model to obtain the area under the plasma concentration versus time curve (AUC) for micafungin to aid in dosing strategies in pediatric patients.
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CAS 208538-73-2 Micafungin Sodium

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