Mibefradil dihydrochloride hydrate - CAS 116666-63-8
Catalog number: 116666-63-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H40Cl2FN3O3
Molecular Weight:
568.55 (anhydrous basis)
COA:
Inquire
Targets:
Calcium Channel
Description:
The dihydrochloride hydrate salt form of Mibefradil which is a calcium channel blocker with modest selectivity for T-type Ca2+ channels so that it could be used in the treatment of sorts of cardiovascular disease like hypertension and chronic angina pecto
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Purity:
95%
Appearance:
Powder
Synonyms:
(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
Solubility:
DMSO 100 mM water 50 mM
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The dihydrochloride hydrate salt form of Mibefradil which is a calcium channel blocker with modest selectivity for T-type Ca2+ channels so that it could be used in the treatment of sorts of cardiovascular disease like hypertension and chronic angina pecto
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
647.6ºC at 760mmHg
InChIKey:
MTJLQTFHJIHXIX-GDUXWEAWSA-N
InChI:
InChI=1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H/t28-,29-;;/m0../s1
Canonical SMILES:
CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F.Cl.Cl
1.The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay.
Major TC1, Dhamija S, Black N, Liachenko S, Morenko B, Sobocinski G, Okerberg C, Tinholt P, Madore S, Kowala MC. J Pharmacol Exp Ther. 2008 Jun;325(3):723-31. doi: 10.1124/jpet.107.133892. Epub 2008 Mar 7.
Among the L-type calcium channel blockers (CCBs), particularly dihydropyridines like nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester], a common adverse effect is vasodilatory edema. Newer CCBs, such as the T- and L-type CCB, mibefradil [(1S,2S)-2-[2[[3-(2-benzimidazolylpropyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate], demonstrate antihypertensive efficacy similar to that of their predecessors but seem to have a reduced propensity to cause edema. Using a magnetic resonance imaging (MRI) T(2) mapping technique, we investigated the ability of mibefradil to reduce extracellular water accumulation caused by the L-type CCB, nifedipine, in the hindleg skeletal muscle of the spontaneously hypertensive rat. Mibefradil (10 mg/kg i.v.) and nifedipine (1 mg/kg i.v.) lowered mean arterial blood pressure by 97 +/- 5 and 77 +/- 4 mm Hg, respectively.
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CAS 116666-63-8 Mibefradil dihydrochloride hydrate

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