Mianserin Hydrochloride - CAS 21535-47-7
Catalog number: 21535-47-7
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Histamine Receptor
Mianserin Hydrochloride is a psychoactive drug of the tetracyclic antidepressant.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.It is not approved for use in the US.
ORG GB-94 HCl; Mianserin hydrochloride; Tolvon; Tolvin; ORG GB 94; Lerivon.
Canonical SMILES:
1.In vivo Schild regression analyses using nonselective 5-HT2C receptor antagonists in a rat operant behavioral assay
Ellen A. Walker & Edward K. Brown Jr. & Steven N. Sterious. Psychopharmacology (2007) 193:187–197
The following drugs were used: BW723C86 hydrochloride, cyproheptadine hydrochloride,mCPP dihydrochloride, ketan-serin tartrate, metergoline phenylmethyl ester, methysergide maleate, mianserin hydrochloride,MK212 hydrochloride, SB 200,646 hydrochloride [N-(1-Methyl-1H-indol-5-yl)-N’-(3-pyridinylurea hydrochloride], SB 204,741 [N-(1-Methyl-1H-indol-5-yl)-N’-(3-methyl-5-isothiazolyl)urea], RS102221 hydrochloride (Tocris Bioscience, Ellisville, MO), (+)-2-bromolysergic acid diethylamide hydrogen tartrate (BOL), morphine sulfate, and naltrexone hydrochloride (generously supplied by the National Institute on Drug Abuse, Rockville, MD). SB 200,646 and SB 204,741 were initially dissolved in a few drops of 8.5% lactic acid and sterile water. Higher concentrations of SB 200,646 and SB 204,741 required sonication just before injection to maintain a solution. All other drugs were dissolved in sterile water. Injections were administered s.c. in the dorsal flank in a volume of 0.5–1.0 ml/kg. Drug doses for all drugs except SB 204,741 are expressed based on milligrams per kilogram of the salt.
2.Management of non-motor complications in Parkinson’s disease
Ken-ichi Fujimoto. J Neurol (2009) 256 (Suppl 3):S299–S305
Selegiline (5 mg), cabergoline (2 mg), and pergolide (1.5 mg) were withdrawn in that order, but the hallucinations/delusions were unchanged. Then the dose of L-dopa/DCI was reduced from 600 to 150 mg after 1 month and mianserin hydrochloride (30 mg) was added. Motor complications were aggravated and she had difficulty walking, but the delusions were unchanged. When a patient believes his/her delusions, the problem may not be detected, as occurred in this case. When delusions are untreated for a long time, progression to paranoia occurs and the condition becomes untreatable. Patients should be questioned during routine examination to detect the presence of psychosis and enable early diagnosis. Because disuse syndrome develops when aggravation of motor symptoms is not treated, subsequent actions should be taken immediately if adjustment of medications is not effective. Modified electroconvulsive therapy (mECT) was immediately performed in this patient. Her delusions completely subsided after mECT was done a total of seven times at a frequency of three times weekly. Then her drug therapy was altered and the state before the development of psychosis was finally restored with L-dopa/DCI (650 mg) and mianserin hydrochloride (20 mg) after dinner.
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CAS 21535-47-7 Mianserin Hydrochloride

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