Mianserin - CAS 24219-97-4
Catalog number:
24219-97-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H20N2
Molecular Weight:
264.3649
COA:
Inquire
Targets:
Histamine Receptor
Description:
Mianserin is a tetracyclic second generation antidepressant. It has the same efficacy as the tricyclics, but has no anticholinergic and cardiovascular side-effects. It also has antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating
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Purity:
95%
Appearance:
Solid powder
Synonyms:
1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine;f)pyrazino(1,2-a)azepine,1,2,3,4,10,14b-hexahydro-2-methyl-dibenzo(;MIANSERIN;MIANSERINE;Dibenzoc,fpyrazino1,2-aazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-;MIANSERIN,1.0MG/MLINMETHANOL;D
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -108℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
411.3ºC at 760mmHg
Density:
1.18 g/cm3
InChIKey:
UEQUQVLFIPOEMF-UHFFFAOYSA-N
InChI:
1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
Canonical SMILES:
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
1.Tricyclic and related drugs for nocturnal enuresis in children.
Caldwell PH1, Sureshkumar P, Wong WC. Cochrane Database Syst Rev. 2016 Jan 20;1:CD002117. doi: 10.1002/14651858.CD002117.pub2.
BACKGROUND: Enuresis (bedwetting) affects up to 20% of five year-olds and 2% of adults. Although spontaneous remission often occurs, the social, emotional and psychological costs can be great. Tricyclics have been used to treat enuresis since the 1960s.
2.The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial.
Buhmann CB1, Nordentoft M2, Ekstroem M2, Carlsson J2, Mortensen EL2. Br J Psychiatry. 2016 Mar;208(3):252-9. doi: 10.1192/bjp.bp.114.150961. Epub 2015 Nov 5.
BACKGROUND: Little evidence exists on the treatment of traumatised refugees.
3.Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
Rangaraju S1,2,3,4, Solis GM1,2,3,4, Thompson RC2, Gomez-Amaro RL1,2,3,4, Kurian L5, Encalada SE2,3,4, Niculescu AB 3rd6, Salomon DR2, Petrascheck M1,2,3,4. Elife. 2015 Dec 1;4:e08833. doi: 10.7554/eLife.08833.
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we uncover transcriptional drift, a phenomenon that describes how aging causes genes within functional groups to change expression in opposing directions. These changes cause a transcriptome-wide loss in mRNA stoichiometry and loss of co-expression patterns in aging animals, as compared to young adults. Using Caenorhabditis elegans as a model, we show that extending lifespan by inhibiting serotonergic signals by the antidepressant mianserin attenuates transcriptional drift, allowing the preservation of a younger transcriptome into an older age. Our data are consistent with a model in which inhibition of serotonergic signals slows age-dependent physiological decline and the associated rise in mortality levels exclusively in young adults, thereby postponing the onset of major mortality.
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CAS 24219-97-4 Mianserin

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