MI-538 - CAS 1857417-10-7
Catalog number:
1857417-10-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H25F3N8OS
Molecular Weight:
566.607
COA:
Inquire
Targets:
Others
Description:
MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
MSDS:
Inquire
Canonical SMILES:
N#CC(N1CC2=CNN=C2)=CC3=C1C=C(O)C(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


OTS514 hydrochloride

The hydrochloride of OTS514. OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor (IC50 = 2.6 nM), with an inhibitory effect on small cell l...

CAS 102040-03-9 Tubeimoside I

Tubeimoside I
(CAS: 102040-03-9)

Tubeimoside I is a triterpene saponin originally isolated from Bolbostemma that exhibits anti-inflammatory, antiviral, anticancer chemotherapeutic, and chemopre...

CAS 537-12-2 Diperodon hydrochloride

Diperodon hydrochloride
(CAS: 537-12-2)

Diperodon hydrochloride is a local anaesthetics designated by chemical abstracts as 3-piperidino-1,2-propanediol dicarbanilate monohydrate.

Ridinilazole
(CAS: 308362-25-6)

Ridinilazole is a non-absorbable small molecule antibiotic for oral administration to treat Clostridium difficile infection (CDI), showed statistical superiorit...

CAS 1493694-70-4 UNC2250

UNC2250
(CAS: 1493694-70-4)

UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC5...

CAS 4431-01-0 Ligustilide

Ligustilide
(CAS: 4431-01-0)

Ligustilide not only has an active dilatory effect on myometrium but also an effective role in reducing the neurogenic and inflammatory pain, thus having the po...

CAS 792957-74-5 ER-000444793

ER-000444793
(CAS: 792957-74-5)

ER-000444793, a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening, inhibits mPTP with an IC50 of 2.8 μM. R-000444793 neither affecte...

CAS 52432-72-1 Oxeladin citrate

Oxeladin citrate
(CAS: 52432-72-1)

Oxeladin citrate is a cough suppressant used to treat all types of cough of various etiologies.

CAS 39011-90-0 Albiflorin

Albiflorin
(CAS: 39011-90-0)

Albiflorin is a major constituent presents in peony root, which possesses therapeutic potential for neurodegenerative diseases.

CAS 24292-60-2 NADP disodium salt

NADP disodium salt
(CAS: 24292-60-2)

NADP disodium salt, also called as Coenzyme II, widely distributed in living matter, is a participant coenzyme in aerobic and anaerobic oxidations.

CAS 200189-97-5 CGP 3466B maleate

CGP 3466B maleate
(CAS: 200189-97-5)

CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in...

CAS 115810-12-3 Tubeimoside II

Tubeimoside II
(CAS: 115810-12-3)

Tubeimoside II is a natural analogue of oleanane type of triterpenoid saponin, showing anti-inflammatory, antitumor, and antitumor-promoting effects.

Gemilukast disodium salt
(CAS: 1232861-64-1)

Protease-Activated Receptor-4

Protease-Activated Receptor-4, a member of the PARs family, is activated by thrombin, trypsin and cathepsin G but also is the agonist o fproteinase-activated re...

CAS 1188-38-1 N-Carbamyl-L-Glutamic acid

N-Carbamyl-L-Glutamic acid
(CAS: 1188-38-1)

N-Carbamyl-L-Glutamic acid is an orphan drug which is applicated for the treatment of hyperammonaemia in patients that has N-acetylglutamate synthase deficiency...

CAS 475203-77-1 Mebeverine Acid

Mebeverine Acid
(CAS: 475203-77-1)

Mebeverine Acid is a metabolite of Mebeverine, an antispasmodic. Mebeverine acid appears to be a valuable marker of oral exposure to Mebeverine.

CAS 58-85-5 Biotin

Biotin
(CAS: 58-85-5)

Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7).

CAS 22608-11-3 Demethoxycurcumin

Demethoxycurcumin
(CAS: 22608-11-3)

Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAP...

CAS 3397-23-7 Ornipressin Acetate

Ornipressin Acetate
(CAS: 3397-23-7)

Ornipressin Acetate, an analogue of Vasopressin, is used as a vasoconstrict or haemostatic and renal agent.

CAS 9002-96-4 Tocofersolan

Tocofersolan
(CAS: 9002-96-4)

Tocofersolan is a synthetic water-soluble version of vitamin E unlike its natural counterpart which are fat soluble . It is polyethylene glycol derivative of α-...

Quick Inquiry

Verification code

Featured Items