|Description||MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).|
AP-24600 is a bio-active chemical, but no detailed information has been published yet.
HTS01037, a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM), and is a competitive antagonist of protein-protein interac...
Psoralen is an active ingredient from Fructus Psoraleae and has anticancer activity.
Palifosfamide tromethamine is a synthetic mustard compound with potential antineoplastic activity. It is an active metabolite of ifosfamide covalently linked to...
Ono-1082 increases cAMP levels in hepatocytes in rats.
BMS-210285 is a synthetic bio-active chemical.
Avoralstat, also known as BCX-4161, is an oral plasma kallikrein (PKK) inhibitor and Bradykinin inhibitor, used to treat hereditary angioedema.
Gluconate Calcium is an calcium supplement used in crop pesticide formulations and also in the treatment of too little calcium in the blood.
This polypeptide is a growth hormone-releasing hormone (GHRH) analogue which is made up of 29 amino acids. Sermorelin is recognized as the shortest fully functi...
Succinyl phosphonate was found to be effective inhibitors of alpha-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial alpha-ketoglu...
M2I-1 is a protein-protein interaction inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC.
Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7).
Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhyth...
Pyriproxyfen is a pyridine-based pesticide which is effective against a variety of arthropoda, in particular to protect cotton crops against whitefly. It is a j...
RSL3, a glutathione peroxidase 4 inhibitor, has been found to show selective response to tumor cells with oncogenic RAS.
Extract from Piper methysticum, enhancing the binding of bicuculline at the γ-amino butyric acid.
MDK35833, also called as Oct3/4-inducer-1, is a potent Oct3/4-inducer, which enhances its transcriptional activity in diverse human somatic cells, implying the ...
Selenomethionine is an essential nutrient that may have a role in other biologically active compounds, especially vitamin E and the enzyme formic dehydrogenase.
Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
Oroxylin A possessed abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a the...