|Description||MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).|
IMM 01 is an agonist of mammalian Diaphanous (mDia)-related formins that inhibits DID–DAD binding (IC50 value 140 nM).
Methyl linolenate, a polyunsaturated fattly acid (PUFA), is an autoxidation product that is used to study the mechanisms and prevention of oxidation/peroxidatio...
D-Glucosamine (Free Base)
An amino sugar, part of the structure of the polysaccharides chitosan and chitin, is made naturally in the form of glucosamine-6-phosphate, and is the biochemic...
Zinc undecylenate is a ungistatic fatty acid used in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
BF844 is a CLRN1N48K stabilizer that can attenuate progressive hearing loss and deafness in an Usher syndrome type III (USH3) mouse model.
ABT 089 dihydrochloride
ABT 089 dihydrochloride is a selective α4β2 nicotinic acetylcholine receptor partial agonist (Ki = 16 nM) with >1000-fold and >10,000-fold selectivity for α4β2 ...
Calcitonin salmon, a calcium regulating hormone, has been shown to be an effective alternative for the treatment of postmenopausal osteoporosis.
NADH (disodium salt)
NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.
Talabostat, also called as PT100 or Val-boroPro, is a potent, nonselective and orally available dipeptidyl peptidase IV(DPP-IV) inhibitor (Ki= 0.18 nM) with ant...
DC 838 is a potent human cyclophilin A (CypA) inhibitor.
Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma.
This active molecular is a bio-active chemical but detailed information has not been published yet.
The sodium salt form of Disufenton, a benzenesulfonate compound, has been found to be a free radical scavenger that was once studied in acute ischaemic stroke t...
R-Morinidazole is the R enantiomer of Morinidazole, wich is a novel 5-nitroimidazole antimicrobial drug. It undergoes extensive metabolism in humans via N+-gluc...
Gap 26 is a gap junction blocker which is corresponding to residues 63 - 75 of connexin 43. Gap 26 was shown to attenuate rhythmic contractile activity of rabbi...
HNGF6A is a humanin analog that increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. HNGF6A enhances glucose sensing in β...
Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3...
Tolazamide, a sulphonylurea derivative, could be a hypoglycemic agent which is commonly used in Type 2 diabetes.
RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G.
NSC-601980 analog is the analog of the NSC601980, which shows antitumor activity in the yeast screening experiment.