MI-538 - CAS 1857417-10-7
Catalog number: 1857417-10-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).
Publictions citing BOC Sciences Products
  • >> More
Solid powder
Canonical SMILES:
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 218795-74-5 IMM 01

IMM 01
(CAS: 218795-74-5)

IMM 01 is an agonist of mammalian Diaphanous (mDia)-related formins that inhibits DID–DAD binding (IC50 value 140 nM).

CAS 301-00-8 Methyl linolenate

Methyl linolenate
(CAS: 301-00-8)

Methyl linolenate, a polyunsaturated fattly acid (PUFA), is an autoxidation product that is used to study the mechanisms and prevention of oxidation/peroxidatio...

CAS 3416-24-8 D-Glucosamine (Free Base)

D-Glucosamine (Free Base)
(CAS: 3416-24-8)

An amino sugar, part of the structure of the polysaccharides chitosan and chitin, is made naturally in the form of glucosamine-6-phosphate, and is the biochemic...

CAS 557-08-4 Zinc undecylenate

Zinc undecylenate
(CAS: 557-08-4)

Zinc undecylenate is a ungistatic fatty acid used in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

CAS 1404506-35-9 BF844

(CAS: 1404506-35-9)

BF844 is a CLRN1N48K stabilizer that can attenuate progressive hearing loss and deafness in an Usher syndrome type III (USH3) mouse model.

CAS 161416-61-1 ABT 089 dihydrochloride

ABT 089 dihydrochloride
(CAS: 161416-61-1)

ABT 089 dihydrochloride is a selective α4β2 nicotinic acetylcholine receptor partial agonist (Ki = 16 nM) with >1000-fold and >10,000-fold selectivity for α4β2 ...

CAS 47931-85-1 Calcitonin salmon

Calcitonin salmon
(CAS: 47931-85-1)

Calcitonin salmon, a calcium regulating hormone, has been shown to be an effective alternative for the treatment of postmenopausal osteoporosis.

CAS 606-68-8 NADH (disodium salt)

NADH (disodium salt)
(CAS: 606-68-8)

NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.

CAS 149682-77-9 Talabostat

(CAS: 149682-77-9)

Talabostat, also called as PT100 or Val-boroPro, is a potent, nonselective and orally available dipeptidyl peptidase IV(DPP-IV) inhibitor (Ki= 0.18 nM) with ant...

CAS 508186-08-1 DC 838

DC 838
(CAS: 508186-08-1)

DC 838 is a potent human cyclophilin A (CypA) inhibitor.

CAS 112665-43-7 Seratrodast

(CAS: 112665-43-7)

Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma.

(CAS: 1204222-85-4)

This active molecular is a bio-active chemical but detailed information has not been published yet.

CAS 168021-79-2 Disufenton Sodium

Disufenton Sodium
(CAS: 168021-79-2)

The sodium salt form of Disufenton, a benzenesulfonate compound, has been found to be a free radical scavenger that was once studied in acute ischaemic stroke t...

(CAS: 898230-59-6)

R-Morinidazole is the R enantiomer of Morinidazole, wich is a novel 5-nitroimidazole antimicrobial drug. It undergoes extensive metabolism in humans via N+-gluc...

CAS 197250-15-0 Gap 26

Gap 26
(CAS: 197250-15-0)

Gap 26 is a gap junction blocker which is corresponding to residues 63 - 75 of connexin 43. Gap 26 was shown to attenuate rhythmic contractile activity of rabbi...

CAS 1093111-54-6 HNGF6A

(CAS: 1093111-54-6)

HNGF6A is a humanin analog that increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. HNGF6A enhances glucose sensing in β...

CAS 50-35-1 Thalidomide

(CAS: 50-35-1)

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3...

CAS 1156-19-0 Tolazamide

(CAS: 1156-19-0)

Tolazamide, a sulphonylurea derivative, could be a hypoglycemic agent which is commonly used in Type 2 diabetes.

CAS 1160928-63-1 RETF-4NA

(CAS: 1160928-63-1)

RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G.

NSC-601980 analog
(CAS: 91757-46-9)

NSC-601980 analog is the analog of the NSC601980, which shows antitumor activity in the yeast screening experiment.

Quick Inquiry

Verification code

Featured Items