|Description||MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).|
The hydrochloride of OTS514. OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor (IC50 = 2.6 nM), with an inhibitory effect on small cell l...
Tubeimoside I is a triterpene saponin originally isolated from Bolbostemma that exhibits anti-inflammatory, antiviral, anticancer chemotherapeutic, and chemopre...
Diperodon hydrochloride is a local anaesthetics designated by chemical abstracts as 3-piperidino-1,2-propanediol dicarbanilate monohydrate.
Ridinilazole is a non-absorbable small molecule antibiotic for oral administration to treat Clostridium difficile infection (CDI), showed statistical superiorit...
UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC5...
Ligustilide not only has an active dilatory effect on myometrium but also an effective role in reducing the neurogenic and inflammatory pain, thus having the po...
ER-000444793, a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening, inhibits mPTP with an IC50 of 2.8 μM. R-000444793 neither affecte...
Oxeladin citrate is a cough suppressant used to treat all types of cough of various etiologies.
Albiflorin is a major constituent presents in peony root, which possesses therapeutic potential for neurodegenerative diseases.
NADP disodium salt
NADP disodium salt, also called as Coenzyme II, widely distributed in living matter, is a participant coenzyme in aerobic and anaerobic oxidations.
CGP 3466B maleate
CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in...
Tubeimoside II is a natural analogue of oleanane type of triterpenoid saponin, showing anti-inflammatory, antitumor, and antitumor-promoting effects.
Gemilukast disodium salt
Protease-Activated Receptor-4, a member of the PARs family, is activated by thrombin, trypsin and cathepsin G but also is the agonist o fproteinase-activated re...
N-Carbamyl-L-Glutamic acid is an orphan drug which is applicated for the treatment of hyperammonaemia in patients that has N-acetylglutamate synthase deficiency...
Mebeverine Acid is a metabolite of Mebeverine, an antispasmodic. Mebeverine acid appears to be a valuable marker of oral exposure to Mebeverine.
Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7).
Natural demethoxy curcuminoid. Anticancer, antiproliferative and antioxidant activity. Inhibits various signaling pathways including Wnt/β-catenin, AMPK and MAP...
Ornipressin Acetate, an analogue of Vasopressin, is used as a vasoconstrict or haemostatic and renal agent.
Tocofersolan is a synthetic water-soluble version of vitamin E unlike its natural counterpart which are fat soluble . It is polyethylene glycol derivative of α-...