MI-538 - CAS 1857417-10-7
Catalog number: 1857417-10-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H25F3N8OS
Molecular Weight:
566.607
COA:
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Targets:
Others
Description:
MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin−MLL interaction with IC50 = 21 nM, and the binding affinity to menin (Kd = 6.5 nM).
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
MSDS:
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Canonical SMILES:
N#CC(N1CC2=CNN=C2)=CC3=C1C=C(O)C(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3
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