|Description||MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.|
SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1), which has an IC50 of 50 nM for CARM1 an...
C7280948 is a novel PRMT1 inhibitor ( IC50=12.75 μM).
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity.
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).
EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectiv...
LLY-507, a lysine N-methyltransferase, is a cell-active, small molecule, and selective inhibitor of Protein-lysine Methyltransferase SMYD2 (IC50 = 15 nM), with ...
BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senesc...
CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 μM and shows very low activity against...
The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia.
A-366 is peptide-competitive inhibitor of the G9a/GLP histone lysine methyltransferase (IC50 = 3.3 nM) and is approximately 1,000-fold selective over other meth...
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifical...
MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs inclu...
MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM.
PFI-2 hydrochloride is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) and is approximately 1,000-fold selective over a panel of 18 other methyltrans...
UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties.
UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity.
UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methy...
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMT...
MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50= 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction...