MI-192 - CAS 1415340-63-4
Catalog number:
1415340-63-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H21N3O2
Molecular Weight:
383.45
COA:
Inquire
Targets:
HDAC
Description:
MI-192 is a selectively histone deacetylases inhibitor (HDACs) that preferentially inhibits HDAC2 with IC50 value of 30 nM and HDAC3 with IC50 value of 16 nM over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively). MI-192 can promote apoptosis of leukemia cell lines in vitro. It also can attenuate IL-6 production in rheumatoid arthritis PBMCs in vitro.
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Purity:
98%
Appearance:
white solid
Synonyms:
N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide
Solubility:
DMSO to 100 mM
Storage:
-20°C Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
GTLTXEIKQVWSRF-UHFFFAOYSA-N
InChI:
1S/C24H21N3O2/c1-16-14-27(24(29)20-7-3-2-6-19(16)20)15-17-10-12-18(13-11-17)23(28)26-22-9-5-4-8-21(22)25/h2-13H,1,14-15,25H2,(H,26,28)
Canonical SMILES:
O=C1N(CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)CC(C4=CC=CC=C41)=C
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