Mexilitine - CAS 31828-71-4
Catalog number: 31828-71-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H17NO
Molecular Weight:
179.26
COA:
Inquire
Targets:
Others
Description:
Mexiletine is a non-selective voltage-gated sodium channel blocker used to treat arrhythmias within the heart, or seriously irregular heartbeats.
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Purity:
≥98%
Appearance:
Solid powder
Synonyms:
1-(2,6-dimethylphenoxy)-2-propanamin; 1-methyl-2-(2,6-xylyloxy)-ethylamin; 1-Methyl-2-(2,6-xylyloxy)ethylamine; 2-Propanamine, 1-(2,6-dimethylphenoxy)-; Ethylamine, 1-methyl-2-(2,6-xylyloxy)-;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Used to treat arrhythmias within the heart, or seriously irregular heartbeats.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
Boiling Point:
271.5ºC at 760 mmHg
Melting Point:
203-205 ºC
Density:
0.979 g/cm3
InChIKey:
VLPIATFUUWWMKC-UHFFFAOYSA-N
InChI:
1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
Canonical SMILES:
CC1=C(C(=CC=C1)C)OCC(C)N
1.Deracemization of mexiletine biocatalyzed by omega-transaminases.
Koszelewski D1, Pressnitz D, Clay D, Kroutil W. Org Lett. 2009 Nov 5;11(21):4810-2. doi: 10.1021/ol901834x.
(S)- as well as (R)-mexiletine [1-(2,6-dimethylphenoxy)-2-propanamine], a chiral orally effective antiarrhythmic agent, was prepared by deracemization starting from the commercially available racemic amine using omega-transaminases in up to >99% ee and conversion with 97% isolated yield by a one-pot two-step procedure. The absolute configuration could be easily switched to the other enantiomer, just by switching the order of the applied transaminases. The cosubstrate pyruvate needed in the first oxidative step was recycled by using an amino acid oxidase.
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CAS 31828-71-4 Mexilitine

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