Mexiletine Hydrochloride - CAS 5370-01-4
Catalog number: 5370-01-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H17NO.HCl
Molecular Weight:
215.72
COA:
Inquire
Targets:
Sodium Channel
Description:
Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
KO1173
MSDS:
Inquire
1.Flecainide-Responsive Myotonia Permanens With SNEL Onset: A New Case and Literature Review.
Portaro S1, Rodolico C2, Sinicropi S2, Musumeci O2, Valenzise M3, Toscano A4. Pediatrics. 2016 Mar 4. pii: peds.2015-3289. [Epub ahead of print]
Sodium channel myotonias are inherited muscle diseases linked to mutations in the voltage-gated sodium channel. These diseases may also affect newborns with variable symptoms. More recently, severe neonatal episodic laryngospasm (SNEL) has been described in a small number of patients. A timely diagnosis of SNEL is crucial because a specific treatment is now available that will likely reduced laryngospasm and improve vital and cerebral outcomes. We report here on an 8-year-old girl who had presented, at birth, with SNEL who subsequently developed myotonia permanens starting at age 3 years. Results of molecular analysis revealed a de novo SCN4A G1306E mutation. The girl was treated with carbamazepine, acetazolamide, and mexiletine, with little improvement; after switching her treatment to flecainide, she experienced a dramatic reduction in muscle stiffness and myotonic symptoms as well as an improvement in behavior.
2.Gene-Specific Therapy With Mexiletine Reduces Arrhythmic Events in Patients With Long QT Syndrome Type 3.
Mazzanti A1, Maragna R1, Faragli A1, Monteforte N1, Bloise R1, Memmi M1, Novelli V1, Baiardi P1, Bagnardi V2, Etheridge SP3, Napolitano C1, Priori SG4. J Am Coll Cardiol. 2016 Mar 8;67(9):1053-8. doi: 10.1016/j.jacc.2015.12.033.
BACKGROUND: Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5. Mexiletine is used to block late sodium current and to shorten QT interval in LQT3 patients.
3.A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Weiss MD1, Macklin EA2, Simmons Z2, Knox AS2, Greenblatt DJ2, Atassi N2, Graves M2, Parziale N2, Salameh JS2, Quinn C2, Brown RH Jr2, Distad JB2, Trivedi J2, Shefner JM2, Barohn RJ2, Pestronk A2, Swenson A2, Cudkowicz ME2; Mexiletine ALS Study Group. Neurology. 2016 Feb 24. pii: 10.1212/WNL.0000000000002507. [Epub ahead of print]
OBJECTIVE: To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS).
4.The Complexity of Pain Management in Patients with Erythromelalgia.
Patel N1, Chen E, Cucchiaro G. A A Case Rep. 2015 Nov 1;5(9):151-3. doi: 10.1213/XAA.0000000000000201.
A 15-year-old girl diagnosed with erythromelalgia was admitted to the hospital with severe pain in her feet associated with burning, pruritus, erythema, and swelling. She had not responded to conventional management and received some relief only from cold bath immersions, which resulted in chronic blistering and multiple episodes of superinfection. After a successful trial of spinal cord stimulation, she had a permanent implantation procedure. The spinal cord stimulator relieved her pain and improved function but not the sensation of burning pain. However, this pain resolved after she started daily mexiletine. This case demonstrates that erythromelalgia sometimes can be managed successfully with a combination of pharmacologic and interventional procedures.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 42971-09-5 Vinpocetine

Vinpocetine
(CAS: 42971-09-5)

Vinpocetine is a Phosphodiesterase inhibitor and selective for PDE1. It also blocks voltage-gated Na+ channels.

CAS 161804-20-2 Benzamil hydrochloride

Benzamil hydrochloride
(CAS: 161804-20-2)

Benzamil hydrochloride is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM) and an epithelial sodium channel (ENaC) blocker. Benzamil is an analogue of amilor...

CAS 1443373-17-8 AM-2099

AM-2099
(CAS: 1443373-17-8)

AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50= 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM).

CAS 1609937-15-6 Mambalgin 1

Mambalgin 1
(CAS: 1609937-15-6)

Mambalgin 1, a toxin isolated from black mamba venom, is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger tox...

CAS 298-46-4 Carbamazepine

Carbamazepine
(CAS: 298-46-4)

Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegr...

CAS 5369-03-9 QX 314 chloride

QX 314 chloride
(CAS: 5369-03-9)

QX 314 chloride, a membrane-impermeant lidocaine derivative, is a blocker of voltage-activated Na+ channels. QX-314 elicits a long-lasting decrease in the respo...

CAS 1211866-85-1 TC-N 1752

TC-N 1752
(CAS: 1211866-85-1)

TC-N 1752 is a state-dependent human NaV channel inhibitor (IC50 = 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9, respectivel...

Funapide
(CAS: 1259933-16-8)

Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...

CAS 54143-56-5 Flecainide Acetate

Flecainide Acetate
(CAS: 54143-56-5)

Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle

CAS 1722-62-9 Mepivacaine HCl

Mepivacaine HCl
(CAS: 1722-62-9)

Mepivacaine is a tertiary amine used as a local anesthetic.

AZD-3161
(CAS: 1369501-46-1)

AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.

CAS 159138-80-4 Cariporide

Cariporide
(CAS: 159138-80-4)

Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity fo...

PF-05241328
(CAS: 1387633-03-5)

PF-05241328, a purely acidic molecule, is a selective inhibitor of human Nav1. 7 voltage-dependent sodium channels (IC50= 31nM) for the treatment of pain. But P...

CAS 130800-90-7 Sipatrigine

Sipatrigine
(CAS: 130800-90-7)

Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) and a glutamate release inhibitor. Sipatrigine exhibits neuroprotective activity in rat mode...

CAS 31883-05-3 Moricizine

Moricizine
(CAS: 31883-05-3)

Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And ...

CAS 925463-91-8 Jingzhaotoxin III

Jingzhaotoxin III
(CAS: 925463-91-8)

Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms...

Nav1.7-IN-2
(CAS: 1332295-35-8)

Nav1.7-IN-2, a voltage-gated sodium channels, could be probably effective in chronic pain therapy. IC50: 80 nM.

CAS 86-35-1 ETHOTOIN

ETHOTOIN
(CAS: 86-35-1)

Ethotoin is an anticonvulsant drug. It is a sodium channel inhibitor. Ethotoin can be used for the treatment of epilepsy. It is a hydantoin, similar to phenytoi...

PF-04856264
(CAS: 1235397-05-3)

This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...

CAS 166196-11-8 CGP-47292

CGP-47292
(CAS: 166196-11-8)

CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.

Chemical Structure

CAS 5370-01-4 Mexiletine Hydrochloride

Quick Inquiry

Verification code

Featured Items