Mexiletine Hydrochloride - CAS 5370-01-4
Catalog number:
5370-01-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H17NO.HCl
Molecular Weight:
215.72
COA:
Inquire
Targets:
Sodium Channel
Description:
Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
KO1173
MSDS:
Inquire
1.Flecainide-Responsive Myotonia Permanens With SNEL Onset: A New Case and Literature Review.
Portaro S1, Rodolico C2, Sinicropi S2, Musumeci O2, Valenzise M3, Toscano A4. Pediatrics. 2016 Mar 4. pii: peds.2015-3289. [Epub ahead of print]
Sodium channel myotonias are inherited muscle diseases linked to mutations in the voltage-gated sodium channel. These diseases may also affect newborns with variable symptoms. More recently, severe neonatal episodic laryngospasm (SNEL) has been described in a small number of patients. A timely diagnosis of SNEL is crucial because a specific treatment is now available that will likely reduced laryngospasm and improve vital and cerebral outcomes. We report here on an 8-year-old girl who had presented, at birth, with SNEL who subsequently developed myotonia permanens starting at age 3 years. Results of molecular analysis revealed a de novo SCN4A G1306E mutation. The girl was treated with carbamazepine, acetazolamide, and mexiletine, with little improvement; after switching her treatment to flecainide, she experienced a dramatic reduction in muscle stiffness and myotonic symptoms as well as an improvement in behavior.
2.Gene-Specific Therapy With Mexiletine Reduces Arrhythmic Events in Patients With Long QT Syndrome Type 3.
Mazzanti A1, Maragna R1, Faragli A1, Monteforte N1, Bloise R1, Memmi M1, Novelli V1, Baiardi P1, Bagnardi V2, Etheridge SP3, Napolitano C1, Priori SG4. J Am Coll Cardiol. 2016 Mar 8;67(9):1053-8. doi: 10.1016/j.jacc.2015.12.033.
BACKGROUND: Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5. Mexiletine is used to block late sodium current and to shorten QT interval in LQT3 patients.
3.A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Weiss MD1, Macklin EA2, Simmons Z2, Knox AS2, Greenblatt DJ2, Atassi N2, Graves M2, Parziale N2, Salameh JS2, Quinn C2, Brown RH Jr2, Distad JB2, Trivedi J2, Shefner JM2, Barohn RJ2, Pestronk A2, Swenson A2, Cudkowicz ME2; Mexiletine ALS Study Group. Neurology. 2016 Feb 24. pii: 10.1212/WNL.0000000000002507. [Epub ahead of print]
OBJECTIVE: To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS).
4.The Complexity of Pain Management in Patients with Erythromelalgia.
Patel N1, Chen E, Cucchiaro G. A A Case Rep. 2015 Nov 1;5(9):151-3. doi: 10.1213/XAA.0000000000000201.
A 15-year-old girl diagnosed with erythromelalgia was admitted to the hospital with severe pain in her feet associated with burning, pruritus, erythema, and swelling. She had not responded to conventional management and received some relief only from cold bath immersions, which resulted in chronic blistering and multiple episodes of superinfection. After a successful trial of spinal cord stimulation, she had a permanent implantation procedure. The spinal cord stimulator relieved her pain and improved function but not the sensation of burning pain. However, this pain resolved after she started daily mexiletine. This case demonstrates that erythromelalgia sometimes can be managed successfully with a combination of pharmacologic and interventional procedures.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sodium Channel Products


CAS 1722-62-9 Mepivacaine HCl

Mepivacaine HCl
(CAS: 1722-62-9)

Mepivacaine is a tertiary amine used as a local anesthetic.

PD 122860
(CAS: 122576-86-7)

This active molecular is a calcium channel antagonist with sodium channel stimulating property as a dihydropyridine. PD 122860 can increase left ventricular con...

CAS 50-12-4 Mephenytoin

Mephenytoin
(CAS: 50-12-4)

Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures...

CAS 934240-30-9 Raxatrigine

Raxatrigine
(CAS: 934240-30-9)

Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, sta...

CAS 95635-55-5 Ranolazine

Ranolazine
(CAS: 95635-55-5)

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

CAS 54143-56-5 Flecainide Acetate

Flecainide Acetate
(CAS: 54143-56-5)

Flecainide Acetate is an antiarrhythmic as a Na+ channel blocker that inhibits fast Na+ current in cardiac muscle

ICA-121431
(CAS: 313254-51-2)

ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant...

CAS 536-43-6 Dyclonine Hydrochloride

Dyclonine Hydrochloride
(CAS: 536-43-6)

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.

CAS 85-79-0 Dibucaine

Dibucaine
(CAS: 85-79-0)

Dibucaine is an anesthetic of the amide type. It is mainly used for surface anesthesia and now restricted to use in spinal and topical anesthesia. It reduced th...

CAS 132112-35-7 Ropivacaine Hydrochloride

Ropivacaine Hydrochloride
(CAS: 132112-35-7)

Ropivacaine hydrochloride is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

PF-05089771
(CAS: 1235403-62-9)

PF-05089771, a Nav1.7 channel blocker, has been studied to have potential effect in the treatment of chronic neuropathic pain. It is still under Phase II clinic...

CAS 298-46-4 Carbamazepine

Carbamazepine
(CAS: 298-46-4)

Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.Carbamazepine (CBZ), first marketed under the tradename Tegr...

AZD-3161
(CAS: 1369501-46-1)

AZD 3161 is a Nav1.7-voltage-gated-sodium-channel-inhibitor originated by AstraZeneca. Phase-I clinical trials in Pain and Neuropathic pain was discontinued.

CAS 34183-22-7 Propafenone hydrochloride

Propafenone hydrochloride
(CAS: 34183-22-7)

Propafenone is a Class 1C antiarrhythmic as sodium channel blocker by slowing the influx of sodium ions into the cardiac muscle cells.

CAS 84057-84-1 Lamotrigine

Lamotrigine
(CAS: 84057-84-1)

Lamotrigine is an anticonvulsant, inhibiting glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

CAS 6108-05-0 Lidocaine hydrochloride monohydrate

Lidocaine hydrochloride monohydrate
(CAS: 6108-05-0)

Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class...

CAS 159138-80-4 Cariporide

Cariporide
(CAS: 159138-80-4)

Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity fo...

GSK-1014802 hydrochloride
(CAS: 934240-31-0)

GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and tri...

CAS 166196-11-8 CGP-47292

CGP-47292
(CAS: 166196-11-8)

CGP-47292, a triazole compound, has been found to be a metabolite of CGP-33101 that could be used agaist Lennox-Gastaut syndrome as a Sodium Channel antagonist.

Sodium Channel inhibitor 1
(CAS: 1198117-23-5)

Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatm...

Chemical Structure

CAS 5370-01-4 Mexiletine Hydrochloride

Quick Inquiry

Verification code

Featured Items