Metrizamide - CAS 31112-62-6
Catalog number: 31112-62-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H22I3N3O8
Molecular Weight:
789.1
COA:
Inquire
Targets:
Others
Description:
Metrizamide is a X-ray contrast agent related to Metrizoic Acid, used as a diagnostic aid (radiopaque medium).
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Purity:
≥98%
Appearance:
White Solid
Synonyms:
2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
X-ray contrast agent related to Metrizoic Acid, used as a diagnostic aid (radiopaque medium).
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
Boiling Point:
828.5ºC at 760 mmHg
Melting Point:
222-224 ºC
Density:
2.35 g/cm3
InChIKey:
BAQCROVBDNBEEB-UBYUBLNFSA-N
InChI:
1S/C18H22I3N3O8/c1-5(26)22-12-9(19)8(10(20)14(11(12)21)24(3)6(2)27)17(30)23-13-16(29)15(28)7(4-25)32-18(13)31/h7,13,15-16,18,25,28-29,31H,4H2,1-3H3,(H,22,26)(H,23,30)/t7-,13-,15-,16-,18?/m1/s1
Canonical SMILES:
CC(=O)NC1=C(C(=C(C(=C1I)C(=O)NC2C(C(C(OC2O)CO)O)O)I)N(C)C(=O)C)I
1.A class of chromatin particles associated with nonhistone proteins.
Paul J, Malcolm S. Biochemistry. 1976 Aug 10;15(16):3510-5.
Unfixed nucleoproteins may be banded isopycnically in metrizamide (2(3-acetamido-5-N-methylacetamido-2,4,6-triiodobenzamido)-2-deoxy-D-glucose) according to the protein/nucleic acid ratio. Unsheared or lightly sheared chromatin bands sharply (p=1.2 g/ml); it has a protein/DNA ratio of 1.4. Chromatin sheared by sonication to approximately 350 base pairs of DNA contains two components with protein/nucleic acid ratios of approximately 1.3 (p=1,185 g/ml) and 2 (p=1.245 g/ml). When chromatin is digested exhaustively with staphylococcal nuclease, two density components are found, one with a protein/DNA ratio of 1.5 (p=1.21 g/ml), the other with a protein/DNA ratio of 2 (p=1.24 g/ml). In both instances the denser particle (p=1.24 g/ml) contains nearly all the nonhistone proteins, while both dense and light fractions contain histones in similar amounts. The base sequence complexity of DNA from the fractions is not distinguishable from that of total DNA and there is no evidence of any concentration of sequences complementary to polysomal polyadenylated RNA molecules.
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CAS 31112-62-6 Metrizamide

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