Metoprolol succinate - CAS 98418-47-4
Catalog number:
98418-47-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C34H56N2O10
Molecular Weight:
652.83
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Metoprolol succinate is a selective β-adrenoceptor antagonist. It is used in treatment of several diseases of the cardiovascular system. It is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
White or white crystalline powder
Synonyms:
2-Propanol, 1-(4-(2-Methoxyethyl)phenoxy)-3-((1-Methylethyl)aMino)-, (+-)-, butanedioate (2:1) (salt);Butanedioic acid 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;Toprol XL;Spesicor Dos;Selozok
Solubility:
10 mM in H2O (free soluble)
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Metoprolol succinate is used in treatment of several diseases of the cardiovascular system. It is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia.
Quality Standard:
USP standard
Shelf Life:
2 month in rt, long time
Quantity:
Kilogram to ton
Boiling Point:
398.6ºC at 760 mmHg
InChIKey:
RGHAZVBIOOEVQX-UHFFFAOYSA-N
InChI:
InChI=1S/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
Canonical SMILES:
CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(CC(=O)O)C(=O)O
1.Sorption of structurally different ionized pharmaceutical and illicit drugs to a mixed-mode coated microsampler.
Peltenburg H1, Timmer N2, Bosman IJ3, Hermens JL2, Droge ST2. J Chromatogr A. 2016 Apr 11. pii: S0021-9673(16)30423-X. doi: 10.1016/j.chroma.2016.04.017. [Epub ahead of print]
The mixed-mode (C18/strong cation exchange-SCX) solid-phase microextraction (SPME) fiber has recently been shown to have increased sensitivity for ionic compounds compared to more conventional sampler coatings such as polyacrylate and polydimethylsiloxane (PDMS). However, data for structurally diverse compounds to this (prototype) sampler coating are too limited to define its structural limitations. We determined C18/SCX fiber partitioning coefficients of nineteen cationic structures without hydrogen bonding capacity besides the charged group, stretching over a wide hydrophobicity range (including amphetamine, amitriptyline, promazine, chlorpromazine, triflupromazine, difenzoquat), and eight basic pharmaceutical and illicit drugs (pKa>8.86) with additional hydrogen bonding moieties (MDMA, atenolol, alprenolol, metoprolol, morphine, nicotine, tramadol, verapamil). In addition, sorption data for three neutral benzodiazepines (diazepam, temazepam, and oxazepam) and the anionic NSAID diclofenac were collected to determine the efficiency to sample non-basic drugs.
2.Effect of permeability enhancers on paracellular permeability of acyclovir.
Ates M1,2, Kaynak MS2, Sahin S1. J Pharm Pharmacol. 2016 Apr 7. doi: 10.1111/jphp.12551. [Epub ahead of print]
OBJECTIVES: According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir.
3.Relationship between cytochrome P450 polymorphisms and prescribed medication in elderly haemodialysis patients.
Parker K1, Aasebø W2, Haslemo T3, Stavem K4. Springerplus. 2016 Mar 22;5:350. doi: 10.1186/s40064-016-1986-y. eCollection 2016.
BACKGROUND: Elderly patients on haemodialysis have a high prevalence of polypharmacy and are at risk of drug-related complications. More than 80 % of all prescribed drugs are metabolized by the cytochrome P450 (CYP) enzyme system. The aims of this study were to describe the prevalence of polymorphism in three CYP isoenzymes and the relationship between CYP polymorphism and prescribed drugs.
4.Impact of the Timing of Metoprolol Administration During STEMI on Infarct Size and Ventricular Function.
García-Ruiz JM1, Fernández-Jiménez R2, García-Alvarez A3, Pizarro G4, Galán-Arriola C5, Fernández-Friera L6, Mateos A7, Nuno-Ayala M5, Aguero J5, Sánchez-González J8, García-Prieto J5, López-Melgar B6, Martínez-Tenorio P9, López-Martín GJ5, Macías A5, Pér J Am Coll Cardiol. 2016 Mar 30. pii: S0735-1097(16)00938-4. doi: 10.1016/j.jacc.2016.02.050. [Epub ahead of print]
BACKGROUND: Pre-reperfusion administration of intravenous (IV) metoprolol reduces infarct size in ST-segment elevation myocardial infarction (STEMI).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CP 59430
(CAS: 86329-06-8)

CP 59430 is an azide analog of prazosin. It is a selective alpha 1-adrenergic receptor antagonist.

CAS 81403-80-7 Alfuzosin

Alfuzosin
(CAS: 81403-80-7)

Alfuzosin is a pharmaceutical drug of the alpha-1 blocker class. It works by relaxing the muscles in the prostate and bladder neck. It is used to treat benign p...

CAS 22664-55-7 Metipranolol

Metipranolol
(CAS: 22664-55-7)

Metipranolol is a non-selective beta blocker used in eye drops to treat glaucoma.

CAS 58020-43-2 Hoku-81

Hoku-81
(CAS: 58020-43-2)

Hoku 81 is a bronchodilator, and one of the metabolites of tulobuterol.

CAS 51781-21-6 Carteolol Hydrochloride

Carteolol Hydrochloride
(CAS: 51781-21-6)

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

MK-351 hydrochloride
(CAS: 884-39-9)

MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive...

CAS 67339-62-2 ARC239 dihydrochloride

ARC239 dihydrochloride
(CAS: 67339-62-2)

ARC239 dihydrochloride is a potent and selective α2 B adrenoceptor antagonist. It is used as an α-adrenoceptor blocking drug. It competitively antagonizes press...

CAS 90038-01-0 Detomidine HCl

Detomidine HCl
(CAS: 90038-01-0)

Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).

Olodaterol Hydrochloride
(CAS: 869477-96-3)

Olodaterol is an ultra-long-acting β adrenoreceptor agonist. It can be used as an inhalation for treating patients with chronic obstructive pulmonary disease (C...

CAS 21498-08-8 Lofexidine hydrochloride

Lofexidine hydrochloride
(CAS: 21498-08-8)

Lofexidine hydrochloride is the hydrochloride salt form of Lofexidine. Lofexidine, an analogue of clonidine, is an α2A-adrenergic receptor agonist for the treat...

CAS 522-48-5 Tetrahydrozoline Hydrochloride

Tetrahydrozoline Hydrochloride
(CAS: 522-48-5)

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.

CAS 161905-64-2 α1 adrenoceptor-MO-1

α1 adrenoceptor-MO-1
(CAS: 161905-64-2)

An S enantiomer which has affinity at alpha 1 adrenergic receptor

CAS 70359-46-5 Brimonidine Tartrate

Brimonidine Tartrate
(CAS: 70359-46-5)

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma ...

CAS 41372-08-1 L-α-Methyl DOPA Hydrate

L-α-Methyl DOPA Hydrate
(CAS: 41372-08-1)

L-α-Methyl DOPA Hydrate is an alpha-adrenergic agonist used as a sympatholytic or antihypertensive.

CAS 51384-51-1 Metoprolol

Metoprolol
(CAS: 51384-51-1)

Metoprolol is a a selective β1 receptor blocker for the treatment of a variety of cardiovascular disorder.

GYKI-16084
(CAS: 185739-21-3)

GYKI-16084 is a postsynaptic alpha2-blocker with the potential to treat benign prostatic hyperplasia.

CAS 59803-98-4 Brimonidine

Brimonidine
(CAS: 59803-98-4)

Brimonidine is α2-Adrenoceptor agonist. It is a drug used as eye drops to treat open-angle glaucoma or ocular hypertension. It acts via decreasing synthesis of ...

CAS 79689-25-1 DG5128

DG5128
(CAS: 79689-25-1)

DG5128, a new oral hypoglycemic agent, is an orally available preferential antagonist of α2-adrenoceptor with 7.4 times higher affinity toward α2-adrenoceptor t...

CAS 67346-49-0 (R,R)-Formoterol

(R,R)-Formoterol
(CAS: 67346-49-0)

(R,R)-Formoterol is a long acting beta-adrenoceptor agonist acts as a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could ...

CAS 65-28-1 Phentolamine Mesylate

Phentolamine Mesylate
(CAS: 65-28-1)

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM.

Chemical Structure

CAS 98418-47-4 Metoprolol succinate

Quick Inquiry

Verification code

Featured Items