Metoprolol succinate - CAS 98418-47-4
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Metoprolol succinate is a selective β-adrenoceptor antagonist. It is used in treatment of several diseases of the cardiovascular system. It is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia.
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White or white crystalline powder
2-Propanol, 1-(4-(2-Methoxyethyl)phenoxy)-3-((1-Methylethyl)aMino)-, (+-)-, butanedioate (2:1) (salt);Butanedioic acid 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;Toprol XL;Spesicor Dos;Selozok
10 mM in H2O (free soluble)
-20°C Freezer
Metoprolol succinate is used in treatment of several diseases of the cardiovascular system. It is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia.
Quality Standard:
USP standard
Shelf Life:
2 month in rt, long time
Kilogram to ton
Boiling Point:
398.6ºC at 760 mmHg
Canonical SMILES:
1.Sorption of structurally different ionized pharmaceutical and illicit drugs to a mixed-mode coated microsampler.
Peltenburg H1, Timmer N2, Bosman IJ3, Hermens JL2, Droge ST2. J Chromatogr A. 2016 Apr 11. pii: S0021-9673(16)30423-X. doi: 10.1016/j.chroma.2016.04.017. [Epub ahead of print]
The mixed-mode (C18/strong cation exchange-SCX) solid-phase microextraction (SPME) fiber has recently been shown to have increased sensitivity for ionic compounds compared to more conventional sampler coatings such as polyacrylate and polydimethylsiloxane (PDMS). However, data for structurally diverse compounds to this (prototype) sampler coating are too limited to define its structural limitations. We determined C18/SCX fiber partitioning coefficients of nineteen cationic structures without hydrogen bonding capacity besides the charged group, stretching over a wide hydrophobicity range (including amphetamine, amitriptyline, promazine, chlorpromazine, triflupromazine, difenzoquat), and eight basic pharmaceutical and illicit drugs (pKa>8.86) with additional hydrogen bonding moieties (MDMA, atenolol, alprenolol, metoprolol, morphine, nicotine, tramadol, verapamil). In addition, sorption data for three neutral benzodiazepines (diazepam, temazepam, and oxazepam) and the anionic NSAID diclofenac were collected to determine the efficiency to sample non-basic drugs.
2.Effect of permeability enhancers on paracellular permeability of acyclovir.
Ates M1,2, Kaynak MS2, Sahin S1. J Pharm Pharmacol. 2016 Apr 7. doi: 10.1111/jphp.12551. [Epub ahead of print]
OBJECTIVES: According to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir.
3.Relationship between cytochrome P450 polymorphisms and prescribed medication in elderly haemodialysis patients.
Parker K1, Aasebø W2, Haslemo T3, Stavem K4. Springerplus. 2016 Mar 22;5:350. doi: 10.1186/s40064-016-1986-y. eCollection 2016.
BACKGROUND: Elderly patients on haemodialysis have a high prevalence of polypharmacy and are at risk of drug-related complications. More than 80 % of all prescribed drugs are metabolized by the cytochrome P450 (CYP) enzyme system. The aims of this study were to describe the prevalence of polymorphism in three CYP isoenzymes and the relationship between CYP polymorphism and prescribed drugs.
4.Impact of the Timing of Metoprolol Administration During STEMI on Infarct Size and Ventricular Function.
García-Ruiz JM1, Fernández-Jiménez R2, García-Alvarez A3, Pizarro G4, Galán-Arriola C5, Fernández-Friera L6, Mateos A7, Nuno-Ayala M5, Aguero J5, Sánchez-González J8, García-Prieto J5, López-Melgar B6, Martínez-Tenorio P9, López-Martín GJ5, Macías A5, Pér J Am Coll Cardiol. 2016 Mar 30. pii: S0735-1097(16)00938-4. doi: 10.1016/j.jacc.2016.02.050. [Epub ahead of print]
BACKGROUND: Pre-reperfusion administration of intravenous (IV) metoprolol reduces infarct size in ST-segment elevation myocardial infarction (STEMI).
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CAS 98418-47-4 Metoprolol succinate

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