Metoclopramide hydrochloride hydrate - CAS 54143-57-6
Catalog number:
54143-57-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H25Cl2N3O3
Molecular Weight:
354.27
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist used to treat nausea and vomitin.
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Purity:
≥98%
Appearance:
White to off-white Solid
Synonyms:
Maxolon; 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrate;hydrochloride
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A dopamine D2 antagonist
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
183-186 °C
InChIKey:
KJBLQGHJOCAOJP-UHFFFAOYSA-N
InChI:
1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2
Canonical SMILES:
CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.O.Cl
Current Developer:
Questcor Pharmaceuticals
1.Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial.
Sinha R1, Shende D2, Maitra S3, Kumar N3, Ray BR3, Mohan VK4. Anesthesiol Res Pract. 2016;2016:4281719. doi: 10.1155/2016/4281719. Epub 2016 Jan 26.
Aim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery. Methods. A total of 136 children (1-15 years) were included. Children received either granisetron (40 mcg/kg) [group G] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group GD]. Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed. PONV severity was assessed for first 24 hours and if score was >2, it was treated with metoclopramide. Postoperative analgesia was administered with intravenous fentanyl and ibuprofen. Results. The demographic profile, muscles operated, and fentanyl requirement were comparable. Complete response to PONV in first 24 hours was observed in 75% (51/68) of children in group G and 76.9% (50/65) of children in group GD, which was comparable statistically (p = 0.
2.Systematic review: Is Metoclopramide more effective than Sumatriptan in relieving pain from migraine in adults in the Emergency Department (ED) setting?
Barleycorn D1. Int Emerg Nurs. 2016 Mar 11. pii: S1755-599X(16)30006-4. doi: 10.1016/j.ienj.2016.02.004. [Epub ahead of print]
Migraine headache is a common disorder; patients attending Emergency Departments (ED) for migraine symptoms internationally account for 1-3% of total ED annual attendances. A systematic review was undertaken of reports comparing the effectiveness of metoclopramide intravenously (IV) with that of sumatriptan subcutaneously (SC), in an ED setting, for the immediate relief of migraine and their measurable effects in relieving pain intensity. Findings of two identified comparable reports confirm the individual efficacy of the study drugs in pain relief. However, whilst one report concludes that there is no statistical or significant clinical advantage for one drug over the other, the other report suggests that metoclopramide has a distinct advantage. One study is well structured methodologically, but the other has significant risk of bias. The analysis of the chosen studies demonstrates the need for rigorous study design and robust reporting requirements to obviate this risk.
3.Gastrokinetic activity of Amorphophallus paeoniifolius tuber in rats.
Dey YN1, Mahor S2, Kumar D3, Wanjari M4, Gaidhani S5, Jadhav A6. J Intercult Ethnopharmacol. 2015 Dec 22;5(1):36-42. doi: 10.5455/jice.20151211063819.
AIM: The tuber of Amorphophallus paeoniifolius (Family-Araceae), commonly called suran or jimikand, has medicinal and food value. It is used in ethnomedicinal practices for correction of gastrointestinal disturbances such as constipation and hemorrhoids. The present study evaluated the effect of A. paeoniifolius tuber on gastrointestinal motor functions.
4.Double-Blind, Randomized, Placebo-Controlled Trial of Metoclopramide for Hypersalivation Associated With Clozapine.
Kreinin A1, Miodownik C, Mirkin V, Gaiduk Y, Yankovsky Y, Bersudsky Y, Lerner PP, Bergman J, Lerner V. J Clin Psychopharmacol. 2016 Mar 30. [Epub ahead of print]
Hypersalivation is a frequent, disturbing, and uncomfortable adverse effect of clozapine therapy that frequently leads to noncompliance. The aim of this study was to examine the efficacy of metoclopramide (dopamine D2 antagonist, antiemetic medication) as an option for management of hypersalivation associated with clozapine (HAC). A 3-week, double-blind, placebo-controlled trial was conducted in university-based research clinics from January 2012 to May 2014, on 58 inpatients treated with clozapine who were experiencing hypersalivation. The subjects were randomly divided into placebo and metoclopramide groups. The starting dose was 10 mg/d. Participants who did not respond were up-titrated 10 mg/d weekly to a total of 30 mg/d during the third week. The number of placebo capsules was increased accordingly up to 3 capsules per day. Primary outcome was the change from baseline to the end of study in the severity of hypersalivation as measured with the Nocturnal Hypersalivation Rating Scale and the Drooling Severity Scale.
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CAS 54143-57-6 Metoclopramide hydrochloride hydrate

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