Metixene - CAS 4969-02-2
Catalog number:
4969-02-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H23NS
Molecular Weight:
309.47
COA:
Inquire
Targets:
Others
Description:
Metixene is an anticholinergic used as an antiparkinsonian agent for the symptomatic treatment of parkinsonism.
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Purity:
≥98%
Appearance:
Solid powder
Synonyms:
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Anticholinergic
Quality Standard:
Enterprise Standard/EP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
MJFJKKXQDNNUJF-UHFFFAOYSA-N
InChI:
1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
Canonical SMILES:
CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
1.Aggregation of antiacetylcholine drugs in aqueous solution: monomer concentrations in non-micellar drug systems.
Attwood D. J Pharm Pharmacol. 1976 Oct;28(10):762-5.
The self-association of the antiacetylcholine drugs, propantheline bromide, methantheline bromide and methixene hydrochloride in aqueous solution, has been examined by surface tension, light scattering and conductimetric methods. Surface tension graphs were similar to those of conventional surfactants, showing apparent critical micelle concentrations (cmc) at distinct inflection points. Surface tension measurements in the presence of increasing amounts of electrolyte indicated a decrease in the apparent cmc with increase in electrolyte concentration for propantheline bromide. Light scattering curves for propantheline bromide in electrolyte solution showed no significant discontinuity attributable to a cmc. A mode of self association involving aggregate growth by the stepwise addition of monomers was assumed and equilibrium constants for the initial stages of the association were evaluated. An increase in the magnitude of the stepwise association constants with increase in electrolyte concentration was noted.
2.Therapeutic action of methixene hydrochloride on Parkinsonian tremor and a description of a new tremor-recording transducer.
Clarke S, Hay GA, Vas CJ. Br J Pharmacol Chemother. 1966 Feb;26(2):345-50.
3.[Effects of methixene hydrochloride on urinary tract calculi: effects as an analgesic and on spontaneous passages of stones].
Sugai T, Kimura S, Niimura K. Hinyokika Kiyo. 1968 Aug;14(8):605-18.
4.THE USE OF METHIXENE HYDROCHLORIDE TO RELIEVE FUNCTIONAL GASTROINTESTINAL DISORDERS.
ABRUZZI W. J New Drugs. 1965 Mar-Apr;5(2):109-13.
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CAS 4969-02-2 Metixene

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