|Description||Methysticin, the first Kava-pyrone isolated from the active constituents of rhizome extracts from Piper methysticum-a shrub indigenous to South Pacific islands, has an anticonvulsant effect and potently inhibits non-toxic NF-κB .|
|Synonyms||(2S)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one methysticin methysticin, ((E)-(+-))-isomer|
|Solubility||Soluble in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -57℃ for long term (months to years).|
|Shelf Life||2 years|
|Boiling Point||496.5±45.0 °C | Condition: Press: 760 Torr|
|Melting Point||129-131 °C|
SN50, a cell-permeable peptide inhibitor of NF- B, prevents tissue destruction (epithelial defects/ulceration) in a mouse cornea after a central alkali burn.
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are re...
Adjudin, formerly called as AF-2364, an analog of lonidamine， attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-sperm...
Methysticin, the first Kava-pyrone isolated from the active constituents of rhizome extracts from Piper methysticum-a shrub indigenous to South Pacific islands,...
Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
Edasalonexent, also known as CAT-1004, is a NF-kappa B inhibitor under the development of Catabasis Pharmaceuticals and Sarepta Therapeutics. It is a Inflammati...
Diethylmaleate, a glutathione-depleting compound, is the diethyl ester of maleic acid and inhibits NF-kB. It is used as a reagent in the synthesis of several or...
Eupatilin, isolated from the leaves of Artemisia argyi Levl.et Vant, inhibits the signalling of MAPK, IKK, NF-κB and eotaxin-1 in bronchial epithelial cells, le...
Sodium salicylate is used in medicine as an analgesic and antipyretic.
PNRI-299 is a selective AP-1 transcription inhibitor without affecting NF-kappaB transcription or thioredoxin.
Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor, inducing apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells...
Didox, synthetic antioxidant, is a strong inhibitor of ribonucleotide reductase (RR) that has been found to reduce the levels of oxidative injury markers in the...
Lipoic Acid, an organosulfur compound, is widely used as dietary supplements and antioxidant. It has been also found to influence the activity of nuclear factor...
Recoflavone, also referred to DA 6034, is a synthetic flavonoid derivative known to possess anti-inflammatory activity in phase Ⅲ clinical trials for the treatm...
CID-2858522 selectively inhibits the NF-κB pathway induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activ...
Oleandrin, also known as PBI-05204, is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically bin...
N-Formyl-Met-Leu-Phe, also called as fMLP, is an endogenous chemotactic peptide for polymorphonuclear leukocyte and a specific ligand of N-formyl peptide recept...
JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of...