Methysergide - CAS 361-37-5
Catalog number:
361-37-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H27N3O2
Molecular Weight:
353.46
COA:
Inquire
Targets:
5-HT Receptor
Description:
Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide for the treatment of vascular headache
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Purity:
≥98%
Appearance:
White Solid
Synonyms:
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; UML 491;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
An ergot derivative that is a congener of lysergic acid diethylamide
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
KPJZHOPZRAFDTN-ZRGWGRIASA-N
InChI:
1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1
Canonical SMILES:
CCC(CO)NC(=O)C1CN(C2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C
1.[Cluster headache treatment].
Donnet A1, Valade D2, Fontaine D3. Presse Med. 2015 Nov;44(11):1188-92. doi: 10.1016/j.lpm.2015.10.003. Epub 2015 Nov 4.
Acute treatment: sumatriptan, oxygen inhalation. Prophylactic treatment: verapamil, lithium carbonate. Transitional treatment.
2.Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus.
David RB1, Roncari CF1, Lauar MR1, Vendramini RC2, Antunes-Rodrigues J3, Menani JV1, De Luca LA Jr4. Physiol Behav. 2015 Nov 1;151:111-20. doi: 10.1016/j.physbeh.2015.07.014. Epub 2015 Jul 11.
Previous studies from our laboratory have shown that methysergide, a serotonergic antagonist, injected into the lateral parabrachial nucleus (LPBN) combined with a pre-load of 2 M NaCl, given by gavage, induces 0.3 M NaCl intake. The mechanisms involved in this paradoxical behavior are still unknown. In the present work, we investigated the effect of serotonergic blockade into the LPBN on hindbrain and hypothalamic activity, gastric emptying and arterial blood pressure in cell-dehydrated rats. Methysergide plus 2 M NaCl infused intragastrically or intravenously promoted 0.3 M NaCl intake in two-bottle tests. In cell-dehydrated rats with no access to fluids, methysergide compared to vehicle increased Fos immunoreactivity in the medial nucleus of the solitary tract, area postrema and non-oxytocinergic cells of the ventral portion of the hypothalamic paraventricular nucleus (PVN). There was no alteration in the number of neurons double-labeled for Fos-ir and oxytocin in the PVN and supraoptic nuclei.
3.Intermittent hypercapnia-induced phrenic long-term depression is revealed after serotonin receptor blockade with methysergide in anaesthetized rats.
Valic M1, Pecotic R1, Pavlinac Dodig I1, Valic Z2, Stipica I1, Dogas Z1. Exp Physiol. 2016 Feb 1;101(2):319-31. doi: 10.1113/EP085161. Epub 2015 Dec 20.
NEW FINDINGS: What is the central question of this study? Intermittent hypercapnia is a concomitant feature of breathing disorders. Hypercapnic stimuli evoke a form of respiratory plasticity known as phrenic long-term depression in experimental animals. This study was performed to investigate the putative role of serotonin receptors in the initiation of phrenic long-term depression in anaesthetized rats. What is the main finding and its importance? Phrenic nerve long-term depression was revealed in animals pretreated with the serotonin broad-spectrum antagonist, methysergide. This study highlights that serotonin receptors modulate respiratory plasticity evoked by acute intermittent hypercapnia in anaesthetized rats. This study was performed to test the hypothesis that intermittent hypercapnia can evoke a form of respiratory plasticity known as long-term depression of the phrenic nerve (pLTD) and that 5-HT receptors play a role in the initiation of pLTD.
4.Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.
Delesalle CJ1, Callens C2, Van Colen I3, Lefebvre RA3. Equine Vet J. 2015 Sep;47 Suppl 48:7. doi: 10.1111/evj.12486_14.
REASONS FOR PERFORMING STUDY: Selective 5-HT4 receptor agonists such as prucalopride are used as human prokinetics, since activation of 5-HT4 receptors on intestinal cholinergic neurons facilitates acetylcholine release. 5-HT4 receptors, linked to adenylyl cyclase, act via generation of cAMP. None of the 4 in vitro studies on 5-HT in horses provided evidence for neuronal 5-HT4 receptors, but none used the protocol as described in human studies [1-4].
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CAS 361-37-5 Methysergide

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