Methylprotodioscin - CAS 54522-52-0
Catalog number:
54522-52-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C52H86O22
Molecular Weight:
1063.23
COA:
Inquire
Targets:
Apoptosis Inducer
Description:
A natural compound, source from roots of Dioscorea opposita Thunb, could block the volt dependent form calcium channel in cellular membrane, and up-regulate the function of sodium pump and calcium pump.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
White powder
Synonyms:
3b,26-Dihydroxy-22a-methoxyfurost-5-ene 3-O-beta-chacotrioside 26-O-beta-D-glucopyranoside; Smilax saponin B
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Antibacterial, promoting blood circulation to remove blood stasis, improve myocardial ischemia
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
169-171 °C
Density:
1.43 g/cm3
InChIKey:
HSSJYSJXBOCKQM-LXNCCRCLSA-N
InChI:
1S/C52H86O22/c1-21(20-66-46-40(61)39(60)36(57)31(18-53)70-46)10-15-52(65-7)22(2)33-30(74-52)17-29-27-9-8-25-16-26(11-13-50(25,5)28(27)12-14-51(29,33)6)69-49-45(73-48-42(63)38(59)35(56)24(4)68-48)43(64)44(32(19-54)71-49)72-47-41(62)37(58)34(55)23(3)67-47/h
Canonical SMILES:
CC1C2C(CC3C2(CCC4C3CC=C5C4(CCC(C5)OC6C(C(C(C(O6)CO)OC7C(C(C(C(O7)C)O)O)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)OC1(CCC(C)COC9C(C(C(C(O9)CO)O)O)O)OC
1.Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
Lee HJ1, Park JS2, Yoon YP1, Shin YJ3, Lee SK4, Kim YS4, Hong JH1, Son KH5, Lee CJ6. Phytomedicine. 2015 May 15;22(5):568-72. doi: 10.1016/j.phymed.2015.03.009. Epub 2015 Mar 26.
BACKGROUND: The root of Asparagus cochinchinensis (Lour.) Merr. has been utilized as mucoregulators and expectorants for controlling the airway inflammatory diseases in folk medicine.
2.In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
Yin J1, Tezuka Y, Kouda K, Le Tran Q, Miyahara T, Chen Y, Kadota S. Planta Med. 2004 Mar;70(3):220-6.
The antiosteoporotic activity of the 90 % EtOH fraction of the water extract of rhizomes of Dioscorea spongiosa and methylprotodioscin, its major constituent, were examined in the model of postmenopausal bone loss using ovariectomized (OVX) rats or mice. After 6 weeks treatment, the proximal tibia of rats or mice and the distal femora of mice were scanned by peripheral quantitative computed tomography (pQCT). Both the 90 % EtOH fraction (100 mg/kg/d) and methylprotodioscin (50 mg/kg/d) significantly inhibited bone loss in bone mineral content (BMC) and bone mineral density (BMD) in total, cancellous and cortical bones, and the decrease in bone strength indexes induced by OVX, without side effect on the uterus.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Apoptosis Inducer Products


CAS 496868-77-0 Adarotene

Adarotene
(CAS: 496868-77-0)

Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the co...

CAS 30636-90-9 (20S)-Protopanaxadiol

(20S)-Protopanaxadiol
(CAS: 30636-90-9)

Protopanaxdiol, an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin extracted from the roots of Panax ginseng C. A. Mey. It is apoptosis...

CAS 488832-69-5 Elesclomol

Elesclomol
(CAS: 488832-69-5)

Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic...

CAS 143360-00-3 SMIP004

SMIP004
(CAS: 143360-00-3)

SMIP004 a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, at low micromolar concentration it upregulated p27 in various prostat...

Desacetylcinobufotalin
(CAS: 4099-30-3)

Desacetylcinobufotalin is apoptosis inducer. shows the inhibition effect to HepG2 cells (IC50 =0.0279μmol/ml) .

CAS 79183-19-0 Apoptosis Activator 2

Apoptosis Activator 2
(CAS: 79183-19-0)

CAS 54522-52-0 Methylprotodioscin

Methylprotodioscin
(CAS: 54522-52-0)

A natural compound, source from roots of Dioscorea opposita Thunb, could block the volt dependent form calcium channel in cellular membrane, and up-regulate the...

CAS 35354-74-6 Honokiol

Honokiol
(CAS: 35354-74-6)

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation.

CAS 553-21-9 Costunolide

Costunolide
(CAS: 553-21-9)

Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-...

CAS 18457-55-1 Perillyl Alcohol

Perillyl Alcohol
(CAS: 18457-55-1)

Perillyl Alcohol, or POH, a monoterpene derived from the mevalonate pathway in plants, induces apoptosis in colon tumor cells.

CAS 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5

Ubiquitin Isopeptidase Inhibitor I, G5
(CAS: 108477-18-5)

Ubiquitin Isopeptidase Inhibitor I, G5, a cell-permeable cross-conjugated unsaturated dienone compound, is an apoptosome-independent caspase and apoptosis activ...

CAS 113558-15-9 Baohuoside I

Baohuoside I
(CAS: 113558-15-9)

A regulator of CXCR4 expression

CAS 960365-65-5 Silvestrol aglycone

Silvestrol aglycone
(CAS: 960365-65-5)

Silvestrol aglycone, extracted from Aglaia foveolata, could induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of e...

CAS 78821-43-9 Epibrassinolide

Epibrassinolide
(CAS: 78821-43-9)

Epibrassinolide is a biologically active compound of the brassinosteroids that can be isolated from various plants. It belongs steroid-derived plant growth regu...

CAS 114899-77-3 Trabectedin

Trabectedin
(CAS: 114899-77-3)

CAS 989-51-5 EGCG

EGCG
(CAS: 989-51-5)

EGCG, also called Epigallocatechin gallate, under the IUPAC name [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxy...

CAS 97207-47-1 Methylisoindigotin

Methylisoindigotin
(CAS: 97207-47-1)

CEP-1612
(CAS: 189036-01-9)

CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model.

(-)-Silvestrol
(CAS: 697235-38-4)

A member of flavagline family of natural products from the genus of Aglaia, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway withou...

CAS 472-15-1 Betulinic acid

Betulinic acid
(CAS: 472-15-1)

betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induc...

Chemical Structure

CAS 54522-52-0 Methylprotodioscin

Quick Inquiry

Verification code

Featured Items