Methylparaben - CAS 99-76-3
Molecular Formula:
Molecular Weight:
Methylparaben is an excipient used as a preservative in foods, beverages and cosmetics.
White Solid
Methyl 4-​Hydroxybenzoate
Soluble in DMSO (slightly), methanol (slightly).
Melting Point:
Canonical SMILES:
1.Irreversible paraben inhibition of glycolysis by Streptococcus mutans GS-5.
Ma Y;Marquis RE Lett Appl Microbiol. 1996 Nov;23(5):329-33.
Parabens were found to inhibit irreversibly glycolysis by the cariogenic dental plaque bacterium Streptococcus mutans GS-5 and to decrease the capacity of the bacterium to lower the pH in dense cell suspensions containing excess glucose. The hierarchy of effectiveness was butyl > propyl > ethyl > methyl paraben. Results of studies of the nature of glycolytic inhibition by butyl paraben indicated that it could act at millimolar concentrations as an irreversible inhibitor of the phosphotransferase system for sugar uptake and was lethal for the bacterium at these same levels. Butyl paraben acted also as a reversible inhibitor of the F-ATPase of the organism. Overall, it appeared that the lethal actions of parabens can be interpreted at least in part as due to irreversible damage to key enzymes, such as those of the phosphotransferase system.
2.Expanded solubility parameter approach. I: Naphthalene and benzoic acid in individual solvents.
Beerbower A;Wu PL;Martin A J Pharm Sci. 1984 Feb;73(2):179-88.
An expanded solubility parameter system was tested in conjunction with the extended Hansen solubility approach and the UNIFAC method to calculate the solubilities of naphthalene and benzoic acid in polar and nonpolar solvents. The expanded parameter system is characterized by delta d for the dispersion force, delta p for dipolar forces, a basic or electron-donor parameter, delta b, and an acidic or electron-acceptor parameter delta a. The correlation between the calculated and observed solubilities of benzoic acid was increased by use of the four-parameter system. An indicator variable was required to bring the solubilities into line in strongly dipolar solvents such as N,N-dimethylformamide. For naphthalene, use of the four-parameter approach proved not to be an improvement over the three-parameter extended Hansen solubility approach. The UNIFAC method was not successful in calculating solubilities of benzoic acid in the 40 polar and nonpolar solvents. A triangular plot of the three Hansen parameters for benzoic acid, p-hydroxybenzoic acid, and methyl p-hydroxybenzoate illustrated the contributions of dispersion, dipolar, and Lewis acid-base (hydrogen bonding) interaction forces among the three benzoic acid compounds and the various classes of solvents.
3.Impact of microbial growth inhibition and proteolytic activity on the stability of a new formulation containing a phytate-degrading enzyme obtained from mushroom.
Spier MR;Siepmann FB;Staack L;Souza PZ;Kumar V;Medeiros AB;Soccol CR Prep Biochem Biotechnol. 2016 Oct 2;46(7):725-33. doi: 10.1080/10826068.2015.1135456.
The development of stable enzymes is a key issue in both the food and feed industries. Consequently, the aim of the current study is to evaluate the impact of various additives (sodium chloride, sodium citrate, mannitol, methylparaben, polyethylene glycol 3350, ethylenediaminetetraacetic acid disodium salt, and a serine protease inhibitor) on the stability of a mushroom phytase produced by solid-state cultivation and recovery. Also observed was the effect of the additives on microbial growth inhibition by monitoring both the change in optical density over 30 days of storage and proteolytic activity. Initially, eight experimental formulations were prepared along with a control. After screening, a 3(2) factorial design was applied to define suitable concentrations of the selected additives. Among the eight formulations tested, the formulation containing NaCl, PEG 3350, and methylparaben retained all of the initial phytase activity after 50 days of storage, with no detected interference from protease activity. Sodium citrate, a metal chelation agent, presented the unusual effect of reducing protease activity in the formulations. Although all formulations presented better phytase stability when compared to the control, NaCl and PEG were both able to prolong the stability of the enzyme activity and also to inhibit microbial growth during storage, making them favorable for application as food and feed additives.
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CAS 99-76-3 Methylparaben

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