Methylene Blue - CAS 61-73-4
Catalog number:
61-73-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H18ClN3S
Molecular Weight:
319.85
COA:
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Targets:
Microtubule/Tubulin | Tau
Description:
Methylene Blue, whose brand name is Calbiochem, inhibits tau filament formation (IC50 = 1.9 μM) and soluble guanylyl cyclase.
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Brife Description:
Inhibits tau filament formation (IC50 = 1.9 μM)
Appearance:
Green solid
Synonyms:
[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium; chloride; Blue N, Methylene; Blue, Methylene; Blue, Swiss; Chromosmon; Methylene Blue; Methylene Blue N; Methylthionine Chloride; Methylthioninium Chloride; N, Methylene Blue; Swiss Blue; Urolene Blue; 61-73-4
Solubility:
Soluble to 10 mM in water and to 10 mM in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -45℃ for long term (months to years).
MSDS:
Inquire
InChIKey:
CXKWCBBOMKCUKX-UHFFFAOYSA-M
InChI:
1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
Canonical SMILES:
CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
1.Methylene blue removal by submerged plasma irradiation system in the presence of persulfate.
Son G1, Lee H2. Environ Sci Pollut Res Int. 2016 Apr 30. [Epub ahead of print]
The submerged plasma irradiation (SPI) system is utilized in applications and implications of many environmental fields as an advanced oxidation technology (AOT). However, ramifications of the SPI-based technologies for water treatment are constrained by the different inadequacies. To overcome this matter, in this study, the influence of added persulfate such as peroxydisulfate (PDS) or peroxymonosulfate (PMS) on the removal efficiency of methylene blue (MB) in the SPI system was investigated. The SPI-PMS system was the most effective for MB removal. Also, the pseudo first order rate constants of MB degradation increased with the increase of persulfate dose, applied voltage, and initial solution pH values. The radical species responsible for both the PDS and PMS-activated systems are likely to be peroxomonosulfate radicals (i.e., SO5 ·-), sulfate radicals (SO4 ·-), and hydroxyl radicals (·OH). Additionally, the persulfate-based SPI system is a novel AOT capable of producing SO4 ·-or ·OH and oxidizing water pollutants at near neutral pH.
2.Degradation of aqueous methylene blue using an external loop airlift sonophotoreactor: Statistical analysis and optimization.
Mohajerani M1, Mehrvar M1, Ein-Mozaffari F1. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 Apr 29:1-14. [Epub ahead of print]
Degradation and mineralization of aqueous methylene blue (MB) are investigated in a bench scale external loop airlift sonophotoreactor. A central composite design along with response surface methodology is employed to model and optimize the sonophotolytic process. A quadratic empirical expression between responses and independent variables (pH and initial concentrations of H2O2 and MB) is derived. The efficiencies of the system for the MB degradation after 10, 15, and 30 min, and total organic carbon reduction after 150 min are considered as responses. The analysis of variance performed high values for the coefficient of determination R2 and adjusted R2 for all four responses. Optimum values of process variables for the maximum degradation and mineralization efficiency are pH 6.6 and initial concentrations of H2O2 and MB are 1,280 and 10.56 mg/L, respectively. With optimal operating conditions, 99.93% and 55.32% MB removal (after 10 min) and TOC reduction (after 150 min) are achieved, respectively.
3.Sensitive analytical performance of folding based biosensor using methylene blue tagged aptamers.
Catanante G1, Mishra RK1, Hayat A2, Marty JL1. Talanta. 2016 Jun 1;153:138-44. doi: 10.1016/j.talanta.2016.03.004. Epub 2016 Mar 4.
This work demonstrates the development of a folding based electrochemical aptasensor using methylene blue (MB) tagged anti-Ochratoxin A (OTA) aptamers. Different aptamer coupling strategies were tested using Hexamethylenediamine, polyethylene glycol, simple adsorption and diazonium coupling mechanism. The best sensitivity was recorded by oxidation of amines using hexamethylenediamine (HDMA) on screen printed carbon electrode (SPCE). To achieve the direct detection of OTA, aptamer conjugated redox probe was used and detection was demonstrated based on the conformational changes in aptamer structure upon OTA sensing. Signaling in this class of sensors arises from changes in electron transfer efficiency upon target-induced changes in the conformation/flexibility of the aptamer probe. These changes can be readily recorded electrochemically. The developed aptasensor is unique in its own mechanism as redox probe tagged aptamer coupling such as MB has never been tried to immobilize using long carbon chain spacers as, addition of spacers would provide more sensitive detection methods.
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CAS 61-73-4 Methylene Blue

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