Methyldopa - CAS 555-30-6
Catalog number: 555-30-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H13NO4
Molecular Weight:
211.21
COA:
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Targets:
Adrenergic Receptor
Description:
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
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Purity:
>98%
MSDS:
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1.A fluorescent sensor based on methyldopa drug modified γ-Fe2O3 nanoparticles for ultrasensitive detection of calf thymus DNA.
Shahabadi N1, Maghsudi M2, Kashanian S3. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:104-9. doi: 10.1016/j.saa.2015.12.023. Epub 2015 Dec 22.
We reported the study of calf thymus DNA (ct-DNA) adsorption by the polymer of methyldopa (2-amino-3-(3,4-dihydroxyphenyl)-2-methyl acid, propanoic) (PMDP), magnetofluorescent PMDP-γ-Fe2O3 nanocrystal. The method is based on the extraordinarily high quenching efficiency of ct-DNA and the specific interaction between ct-DNA and PMDP-γ-Fe2O3 via guanine base and metal coordination, probably. It was found that the designed magnetic nanoparticles can adsorb ct-DNA in nM levels in the presence of NaCl and KCl. In acetate and phosphate buffers DNA were adsorbed completely. Also, we found that pH plays an important role in DNA adsorption onto PMDP-γ-Fe2O3 nanocrystal. PMDP-γ-Fe2O3 nanocrystal is highly hydrophilic and DNA desorption wasn't observed. We believe this study will further stimulate the application of PMDP-γ-Fe2O3 nanocrystal in bioanalytical chemistry and nanotechnology. PMDP-γ-Fe2O3 nanocrystal possesses the ability to interact with ct-DNA via a partial intercalative binding mechanism, as demonstrated by fluorescence displacement experiments and a significant red shift (ca, 10nm) in UV-vis spectra.
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CAS 555-30-6 Methyldopa

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