Methyl linolenate - CAS 301-00-8
Catalog number: 301-00-8
Category: Inhibitor
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Molecular Formula:
C19H32O2
Molecular Weight:
292.46
COA:
Inquire
Targets:
Others
Description:
Methyl linolenate, a polyunsaturated fattly acid (PUFA), is an autoxidation product that is used to study the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids.
Appearance:
Colorless clear liquid
Synonyms:
methyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoate 9,12,15-octadecatrienoic acid, methyl ester linolenic acid methyl ester methyl linolenate methyl linolenate, (Z,Z,Z)-isomer
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -58℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Boiling Point:
182 °C
Melting Point:
-57 °C
Density:
0.8982 g/cm3
InChIKey:
DVWSXZIHSUZZKJ-YSTUJMKBSA-N
InChI:
1S/C19H32O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21-2/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3/b5-4-,8-7-,11-10-
Canonical SMILES:
CCC=CCC=CCC=CCCCCCCCC(=O)OC
1.Oxidative DNA damage induced by potassium bromate in isolated rat renal proximal tubules and renal nuclei.
Sai K;Tyson CA;Thomas DW;Dabbs JE;Hasegawa R;Kurokawa Y Cancer Lett. 1994 Nov 25;87(1):1-7.
Oxidative damage caused by potassium bromate (KBrO3), a rat renal carcinogen, was investigated using in vitro preparations of rat renal proximal tubules (RPT) and renal nuclear fractions. Release of lactate dehydrogenase and decrease of SH-group content in RPT (1 mg protein/ml) by KBrO3 (0.5-5 mM) in a concentration- and time-dependent manner were observed. Peroxidized arachidonic acid and 8-hydroxydeoxyguanosine (8-OH-dG) levels in RPT were increased after administration of 2 and 5 mM KBrO3. 8-OH-dG formation was observed after incubation of renal nuclei with a lipid-peroxiding system, autooxidized methyl linolenate, or KBrO3. These findings provide support for involvement of lipid peroxidation in producing oxidized DNA damage by KBrO3 directly to RPT, the target site for renal carcinogenesis.
2.Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells.
Kuo DH;Hung MC;Hung CM;Liu LM;Chen FA;Shieh PC;Ho CT;Way TD Food Chem. 2012 Oct 1;134(3):1320-6. doi: 10.1016/j.foodchem.2012.03.023. Epub 2012 Mar 16.
Burdock (Arcticum lappa L.) root is used in folk medicine and also as a vegetable in Asian countries. In the present study, burdock root treatment significantly reduced body weight in rats. To evaluate the bioactive compounds, we successively extracted the burdock root with ethanol (AL-1), and fractionated it with n-hexane (AL-2), ethyl acetate (AL-3), n-butanol (AL-4), and water (AL-5). Among these fractions, AL-2 contained components with the most effective hypolipidemic potential in human hepatoma HepG2 cells. AL-2 decreased the expression of fatty acid synthase (FASN) and inhibited the activity of acetyl-coenzyme A carboxylase (ACC) by stimulating AMP-activated protein kinase (AMPK) through the LKB1 pathway. Three active compounds were identified from the AL-2, namely α-linolenic acid, methyl α-linolenate, and methyl oleate. These results suggest that burdock root is expected to be useful for body weight management.
3.Depletion of docosahexaenoic acid in retinal lipids of rats fed a linolenic acid-deficient, linoleic acid-containing diet.
Tinoco J;Miljanich P;Medwadowski B Biochim Biophys Acta. 1977 Mar 25;486(3):575-8.
Rats were raised for 2 generations on a diet in which 1.25% methyl linoleate was the only source of fat. Control rats were given 1.0% methyl linoleate plus 0.25% methyl linolenate. Lipids were extracted from retinas and their fatty acids were analyzed by gas-liquid chromatography. Docosahexaenoic acid accounted for 33.8% of total fatty acids in control retinas, for 13% of fatty acids in first-generation deficient retinas, and for 2.7% of fatty acids in second-generation deficient retinas.
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CAS 301-00-8 Methyl linolenate

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